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Articles by S.O. Okeniyi
Total Records ( 9 ) for S.O. Okeniyi
  P.A. Egwaikhide , S.O. Okeniyi , E.E Akporhonor and S.O. Emua
  Hexane, ethyl acetate and methanolic extracts of dried powdered leaves of Eucalyptus globulus were screened for basic secondary metabolites and antibacterial activity against C. pyogenes, S. aureus, S. faecallis, B. stearothermophilus, S. epidermidis, B. cereus, B. polymyxa, K. pneumonia, P. aeruginosa, B. anthacis, B. subtilis, E. coli, P. fluorescens and C. sporogenes. Phytochemical investigation of crude extracts of Eucalyptus globulus (leaf) revealed the presence of tannins, phlobatannins, saponins, flavonoids, steroids, terpenoids, cardiac glycosides and reducing sugar in the plant. The antimicrobial sensitivity of the extracts against four species of Gram-ve and ten Gram+ve bacterial stain for Eucalyptus globulus (leaf) revealed very high antimicrobial activity. The extracts of hexane, ethylacetate and methamol of Eucalyptus globulus (leaf) were all very active on almost all the bacterial strains. The Infra Red (IR) spectra revealed the presence of different functional groups ranging from OH (3406-3338.6 cm 1) stretching, C-H (2926.6 cm 1, 864.1 cm 1) stretching alkyl, methyl C = 0, (2162.1 cm ) anhydrides, C = C (1697.6 cm 1) aromatic ring sretching, C-0 (1310.6-1059 cm 1) alcohol, ethers, esters, carboxalic acid bending.
  S.O. Okeniyi , P.A. Egwaikhide , E.E. Akporhonor and S.A. Emua
  Comparative analysis of the acetylene induced ripened and naturally ripened mango and banana fruits were studied. The Kinetic studies on the rate of decrease in total acidity were also investigated. The vitamin C contents of induced mango and banana fruits were 25.50 and 25.09 mg 100g 1, respectively while naturally ripened mango and banana fruits were 24.53 and 24.40 mg 100g 1. The total percentage sugar in induced mango and banana fruits were 22.06 and 21.06%, while naturally ripened mango and banana were 21.06 and 20.63%, respectively. The vitamin C (ascorbic acid) content and total percentage sugar data were higher than the naturally ripened fruits. The Kinetic studies of the rate of decrease of the total acidity gave a first order rate constant (K) for mango and banana juice as 1.510-2h-1 and 1.2+10-2h-1, respectively while the t1/2 ranged 57.75-46.20 and 69.30-57.75 h for the induced mango and banana fruits. There was a sharp decrease in the total acidity of the induced fruits against the naturally ripened ones.
  S.M. Oyeyemi , S.O. Okeniyi and I.O. Olaniyan
  Castor plant, formerly known only for its laxative properties, is becoming popular in the modern world due to the commercial value of industrial vegetable oil it contains. Therefore, there is the need to improve the yield of its seeds through optimal selection of soil needed for its planting. This study presents the effect of physical soil properties such as bulk density, PH, soil texture, electrical conductivity and porosity on the early growth stages of castor plant and the prospect of the castor seed farming in the development of small-scale industries.
  S.O. Okeniyi , J.A. Kolawole , M.T. Odunola , O.A. Babatunde and J.T. Bamgbose
  Aqueous solution of chloramphenicol, plain and ophthalmic preparations were exposed to sunlight, ultraviolet radiation at 365 mm wavelength and red light for varying length of time. The kinetics of decomposition was studied using TLC techniques and U.V. Spectrophotometric methods of analysis of chloramphenicol and decomposing products. The rate of decomposition followed first rate reaction and the K value obtained were 3.386 x 10-2 h-1, .149 x 10-2 h-1 and 0.0659 x 10-2 h-1 in sunlight, ultraviolet radiation and red-light, respectively. The respective half-life (t) of the decomposition was 20.47 h, 2.0 h and 1051.59 h. The average K value for the ophthalmic chloramphenicol preparations were 3.291 x 10-2 h-1 and 3.540 x 10-1 h-1 in sunlight and ultraviolet radiation respectively. The stability of chloramphenicol aqueous solution is established in the presence of red light.
  S.O. Okeniyi and M.T. Odunola-Bakare
  In vivo bioavailaibility studies of nifedipine tablets were carried out in six healthy human subjects in fasting state and after a low-fat meal. A simple, reliable and rapid HPLC method of nifedipine estimation preceded by an extraction technique was employed for the determination of plasma and saliva nifedipine levels. Pharmacokinetic parameters were generated by computer application. The low fat meal taken appeared to reduce the absorption rate constant of nifedipine, in plasma and saliva from 0.96h-10.104 to 0.57h-10.168 and 0.86h-10.38 to 0.41h-10.03 respectively and increase the lag time in plasma and saliva from 0.13h0.37 to 0.36h0.58 and 0.17h0.08 to 0.34h0.18, respectively.
  C.A. Obafemi , S.O. Okeniyi , O.A.Ogunbinu , T.O. Olomola and J.T.Bamgbose
  A modified Clevenger hyrodistillation apparatus was used to obtain essential oils from the leaf, stem bark and root of Vitellaria Paradoxa plant. Thin Layer Chromatographic (TLC) analysis of the oils in 1:1 and 3:1 hexane-ethyl acetate solvent mixtures gave Retention Index (RI) values indicative to the likely presence of geraniol, -pinene, D-carvone, L-carvone, Eugenol and citral. Antimicrobial and antifungal screening of the oils using a good number of pathogenic microorganism at 50-300 mg mL 1 concentrations indicated high activity on a large number of bacteria and fungi.
  S.O. Okeniyi
  A total of 36 samples of three sulphur containing drugs, viz.: chlorpropamide, Ampicillin and frusemide from three different companies labelled A, B and C commonly dispensed to officers, cadets and civilian staff of the Nigerian Defence Academy were tested for their potency using the U.V spectrophotometer assay method. The total drug content, percentage active ingredients, chemical assay and dissolution rate studies for the drugs were evaluated. The specified chemical tests were carried out on the samples analysed and the results were in conformity with that described in BP 1993. The drug contents and percentage active ingredients were found to be within acceptable limit of the monograph. The dissolution rate study of chlorpropamide using the BP 1993 method and pH dependent dissolution rate studies of Ampicillin and Frusemide were investigated on physiological buffer solution pH 6.8. The results obtained demonstrated very good dissolution rate profiles and are discussed in the light of high rate of faking, adulteration and manufacture of substandard drugs and their implication.
  U.A. Birnin-Yauri , Saidu Garba and S.O. Okeniyi
  The effect and mechanism of chloride ion concentration of portland cement concrete and the structural steel reinforcement was investigated. At low concentrations, chloride ion has little or no effect on the physical stability of concrete structure but it causes the corrosion of the re-enforcing steel in the concrete but at high concentration and especially at low temperature, it causes expansion and cracking in the concrete. The degradation is usually accompanied by formation of calcium oxychloride salts. The mechanism for this destruction was discovered in this work as a result of the thermal transformations of the calcium oxychloride salts: 3CaO.CaCl2.15H2O to CaO.CaCl2. 2H2O.
  S.O. OKENIYI
  Salivary and plasma nifedipine concentrations were measured in 6 healthy volunteers. A correlation of 0.965 (P < 0.001) was observed between salivary and plasma nifedipine concentrations. The level of significance of maximum concentration (Cmax) between plasma and saliva was statistically significant (P < 0.001). Identical salivary and plasma nifedipine time to peak drug levels (tmax) was established. Peak salivary concentration (Cmax) ranged from 59.57ng to 63.90ng while peak plasma concentrations ranged from 35.95ng to 39.40ng. Results suggest salivary nifedipine concentration to be of value in bioavailability and pharmacokinetic studies.
 
 
 
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