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Articles by S.O. Bello
Total Records ( 2 ) for S.O. Bello
  E.U. Etuk , P.A. Onyeyili and S.O. Bello
  A comparative pharmacokinetic study of chloramphenicol (25 mg kg-1 intravenous) by chemical assay method and its combination with sulphamethazine (33 mg kg-1) in Sokoto red goats has revealed that the mean peak plasma concentrations at 0.08 h post drug administration were not significantly different. However, various pharmacokinetic parameters were significantly altered (p<0.05) after the combination therapy; the total body clearance (Cl) and elimination constant (β) were significantly higher whereas the half life of elimination (t½ β) and the distribution rate constant were significantly lower. These changes observed in this study could be an indication that, the combination therapy may require a reduced chloramphenicol dose without necessarily minimising the efficiency of the drug and this may also possibly reduce the risk of dose-related toxicity.
  S.O. Bello , B.Y. Muhammad , K.S. Gammaniel , I. Abdu-Aguye , H. Ahmed , C.H. Njoku and U.H, Salka
  The efficacy and tolerability of Solanum melongena and placebo in moderate to Severe asthmatics was evaluated in a randomized, single center, three-arm, triple blind placebo controlled trial in a tertiary hospital setting in Sokoto, Nigeria . The Main outcome measures were weekly disease severity score, daily Salbutamol (Ventolin) inhaler use. Weekly FEV 1 and PEF all expressed as % above baseline and PEF% predicted. Incidence of side effects was the secondary outcome measure. The study revealed significant improvement in all outcome measures over placebo in the two test arm but no significant difference between test arms. At the end of two weeks of daily intake, the dried fruit of Solanum melongena significantly improves asthma symptoms and signs and disease severity score and apparently have a salbutamol sparing effect. No adverse effect was noted.
 
 
 
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