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Articles by S.M.K. Naqvi
Total Records ( 2 ) for S.M.K. Naqvi
  Vijay Kumar Saxena , Sameer Srivastava , Satish Kumar and S.M.K. Naqvi
  Kisspeptin, also called as metastin, is the cognate ligand GPR-54 (G-coupled receptor) which was previously an orphan receptor. Kisspeptin consists of 145 amino acids and its biological activity can be localized to the C-terminal segment which is cleaved into C-10, C-13 and C-14 segment. Kisspeptin-GPR-54 interaction stimulates GnRH secretion and has been shown to be essential for the initiation of the pubertal LH surge. A 13 amino acid derivative of kisspeptin was synthesized by solid phase peptide synthesis using F-moc strategy and it was purified using RP-HPLC. The CD spectra of the peptide (1 mg mL-1) was evaluated in water, 50% and 75% TFE. The CD spectra of kisspeptin 13 in the water mainly exhibited random coil structure with no significant alpha helical or beta sheet content. Increasing concentration of TFE could cause slight induction of both beta sheet and alpha helix structures but still disordered random coil being the major contributor to the conformation. Predominantly disordered structure of kisspeptin 13 as elucidated by the experiment may explain its multifunctional role and non putative receptor binding and may help to develop a few agonists for mimicking the therapeutic action for future drug use.
  V. Sejian , T.V. Meenambigai , M. Chandirasegaran and S.M.K. Naqvi
  Farm animal selection and reproduction are on the threshold of the application of new biotechnologies. Modern biotechnologies will allow advances to be made. Research into physiology and embryology has provided a basis for the development of technologies that increase productivity of farm animals through enhanced control of reproductive function. The livestock provides many opportunities to utilize these disciplines and evolving competencies. Artificial insemination, embryo transfer, in vitro fertilization, cloning, transgenics and genomics all are components of the tool box for present and future applications. Understanding the mechanisms that regulate reproductive function has important implications for this diverse field. Several peptides play a role in determining the normal functioning of the neuroendocrine regulation of reproduction. Kiss1 neurons have emerged as primary transducers of internal and environmental cues to regulate the neuroendocrine reproductive axis. Leptin serves as a metabolic signal that acts on the hypothalamic-pituitary-ovarian axis to enhance GnRH and LH secretion and ovarian function. Leptin effects on Gonadotropin-Releasing Hormone (GnRH) /LH secretion are mediated by NPY and kisspeptin. In recent years, livestock productivity has been increased by improved reproduction. Various techniques have been developed and refined to obtain a large number of offspring from genetically superior animals or obtain offspring from infertile animals. These techniques include: artificial insemination, cryopreservation of gametes or embryos, induction of multiple ovulations, embryo transfer, in vitro fertilization, sex determination of sperm or embryos, nuclear transfer, cloning, etc. Further the wide development radio-immuno-assay technology offers wide scope for improving the reproductive efficiency of farm animals. RIA technique for early non-pregnancy diagnosis can be integrated in to AI programmes in order to increase their effectiveness, reduce the unproductive period of dairy cows and increase the economic benefits to farmers. The greater challenge lies ahead for animal researchers is to integrate and potentially exploit these novel technologies in a society-friendly manner. Accepting this challenge and working towards achieving such targets should enable us to reap maximum benefits from the farm animal sector.
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