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Articles by S.M. Salhimi
Total Records ( 2 ) for S.M. Salhimi
  H.B. Sahib , A.F. Aisha , M.F. Yam , M.Z. Asmawi , Z. Ismail , S.M. Salhimi , N.H. Othman and A.M.S. Abdul Majid
  Angiogenesis is a process by which new blood vessels are formed from the pre-existing blood vessel. Orthosiphon stamineus Benth. OS has been used as a medicinal herb for many centuries. Due to the presence of high level of anti-oxidants and phenolic content compounds in OS and the effect of anti-oxidants and phenolic compounds being anti-angiogenic, the perturbation of new blood vessels ability of OS was tested. Dry powdered leaves of the OS plant were extracted with Petroleum Ether (PE), chloroform (CE), methanol (ME) and water (WE) by using sequential cold maceration method. The ME of OS has the highest anti-angiogenic activity (93.28±1.24%) in the rat aortic assay followed by CE (85.55±1.64%), PE (51.54±4.12%) and WE (50.22±1.23%) in descending order of reactivity. The methanol extract was also found to have potent anti-oxidant activity in the1, 1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay. The IC50 value was measured to be 0.286 mg mL-1. The total phenolic content of 1 mg mL-1 of methanol extract was equal to 38.27%.
  A.F. Mutee , S.M. Salhimi , M.F. Yam , C.P. Lim , G.Z. Abdullah , O.Z. Ameer , M.F. Abdulkarim and M.Z. Asmawi
  Peperomia pellucida is widely used in the traditional medicine such as in the treatment of inflammation, gout, arthritis and wound healing. The present study was performed to evaluate the anti-inflammatory and antioxidant effects of petroleum ether, chloroform and methanol extracts of P. pellucida. The carrageenan-induced rat hind paw edema method was performed to evaluate the anti-inflammatory effect in vivo and the determination of free radical scavenging activity method was carried out to assess the antioxidant effect in vitro. For the anti-inflammatory activity, 1000 mg kg-1 of petroleum ether extract significantly reduced carrageenan-induced hind paw edema (p<0.05) compared with the control (p<0.01). However, there was no significant anti-inflammatory activity for chloroform and methanol extracts. The antioxidant effect was evaluated by determining the free radical scavenging activity of the three extracts. The total phenol content was determined for the methanol extract (6.93%) that showed the strongest free radical scavenging activity (0.083 mg mL-1 ±0.008). Petroleum ether and chloroform showed low free radical scavenging activity compared to methanol extract. The results obtained from this study suggest that this plant is a good natural source for anti-inflammatory and antioxidant therapy.
 
 
 
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