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Articles by S.M. Mosaad
Total Records ( 2 ) for S.M. Mosaad
  S.M. Mosaad , K.I. Mohammed , M.A. Ahmed and S.G. Abdel-Hamide
  In the present study 2-(4-Chlorophenyl)-6-iodo-3, 4-dihydroquinazolin-4-one 3 was prepared by the reaction of 2-(4-chlorophenyl)-6-iodo-4H-3,1-benzoxazin-4-one 2 with formamide. Treatment of 3 with phosphorus penta sulfide yielded the thione derivative 4. Alkylation of 3 and 4 with certain alkylhalides gave the target compounds. The structure of the new compounds was confirmed by 1H NMR, IR and MS. Some of the new compounds were screened for antitubercular activity, the 4-alkylthio derivatives were active while the 4-alkyloxy derivatives were inactive.
  S.M. Mosaad , K.I. Mohammed , M.A. Ahmed and S.G. Abdel-Hamide
  A new series of anthranilic acid derivatives were prepared through reaction of 2-(4-chlorophenyl)-6-iodo-4(H)-3,1-benzoxazine 3 with some amines. Reaction of {2-(4-chlorophenyl)-3-amino-6-iodo-3,4-dihydro-quinazolin-4-one} 6 and {2-(4-chlorobenzoyl-amino)-5-iodobenzoic acid hydrazide} 7 with some aldehydes and acid anhydrides was also reported. The structures of the new compounds were confirmed by microanalyses and spectral data. Some compounds showed promising antibacterial activities against Staphylococcus aureus and Bacillus Subtillis. Compounds 5h and 5K showed the highest activity (MIC = 12.5 μg ml-1), compound 12 a (MIC = 20.0 μg ml-1), compounds 5 a-g, 5 I, 5 j, 6 r,  9 a-h, (MIC = 50 μg ml-1) and compounds 8 g, 12 b, 12 c, (MIC = 100 μg ml-1).
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