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Articles by S.M. Lee
Total Records ( 2 ) for S.M. Lee
  J.Y. SEO , I.S. SHIN and S.M. LEE
  Two feeding experiments were conducted to investigate the effects of dietary inclusion of different plant ingredients on growth and body composition of juvenile sea cucumber. In the first experiment, three replicate groups of the sea cucumber (average weight of 1.5 ± 0.05 g) were fed one of the seven experimental diets containing Sargassum thunbergii (CON), Undaria (UND), Laminaria (LAM), Brassica oleracea L. var. capitata (BRA), fermented soybean (FSB), distillers dried grain (DDG) and rice straw powder (RIC) for 10 weeks. After the feeding trial, survival was not significantly different among the dietary treatments. Specific growth rate (SGR) of sea cucumber fed the FSB diet (0.73) was significantly higher than that of sea cucumber fed the other diets (< 0.05), except for the DDG diet (0.64). The lowest SGR was observed in sea cucumber fed the CON diet (0.14). Based on the result of the first experiment, the second experiment was conducted to determine the proper level of dietary DDG for growth of juvenile sea cucumber. Three replicate groups of sea cucumber (average weight of 1.6 ± 0.02 g) were fed one of the five experimental diets containing different levels (g kg−1) of DDG (DDG0, DDG10, DDG20, DDG30 and DDG40) for 12 weeks. Survival was not significantly different among the treatments (P > 0.05). The best SGR was obtained in sea cucumber fed the DDG10 diet (10.1) and the value of sea cucumber fed the DDG40 diet (5.6) was the lowest (P < 0.05). The SGR of sea cucumber fed the DDG10 diet did not differ from that of sea cucumber fed the DDG20 diet (P > 0.05). Moisture, crude protein, crude lipid and ash contents of whole body in sea cucumber among the dietary treatments (P > 0.05) did not differ significantly at both experiments. Results of two feeding trial suggest that dietary inclusion with 100 g kg−1 FSB or 100–200 g kg−1 DDG may improve growth of juvenile sea cucumber, and especially DDG could be used as a good ingredient for the low-cost feed formulation.
  I. Lee , J. Yu , Y. Yoon , H.J. Gim , S.M. Lee , J.W. Park , R. Jeon and B.H. Park
  The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) plays an important role in adipocyte differentiation and is the target for anti-diabetic drugs known as thiazolidinediones. Here, we synthesized and characterized a new PPARγ agonist, SPA0432. COS-7 cells treated with SPA0432 showed significantly increased PPARγ transcriptional activity compared to that of vehicle-treated cells. However, its efficacy was less than that of rosiglitazone. Using a standard differentiation protocol, SPA0432 effectively enhanced differentiation of 3T3-L1 preadipocytes as evidenced by increased lipid droplet formation and triglyceride accumulation. Real-time RT-PCR analysis indicated that SPA0432 significantly increased the expressions of adipogenesis-related genes, CAAT/enhancer binding protein α, PPARγ, fatty acid synthase, aP2 and lipoprotein lipase and significantly decreased the expression of Pref-1, a preadipocyte marker. Moreover, SPA0432 increased insulin-stimulated glucose uptake in differentiated 3T3-L1 adipocytes. These results suggest that SAP0432 may exert beneficial effects against insulin resistance through its ability to promote adipocyte differentiation and insulin-stimulated glucose uptake.
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