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Articles by S.M. Raquibul Hasan
Total Records ( 2 ) for S.M. Raquibul Hasan
  S.M. Raquibul Hasan , Mariam Jamila , Muntasir Mamun Majumder , Raushanara Akter , Md. Mokarram Hossain , Md. Ehsanul Hoque Mazumder , Md. Ashraful Alam , Rumana Jahangir , Md. Sohel Rana , Md. Arif and Shafiqur Rahman
  Problem statement: Mikania scandens (L.) Willd., a medicinal plant, is popularly used as herbal remedy for various ailments in Bangladesh. But the scientific basis for its medicinal use especially in pain and inflammation remains unknown. Therefore, the present study was designed to evaluate analgesic and antioxidant potential of the hydromethanol extract of the leaves of the plant. Approach: The analgesic activity was determined for its central and peripheral pharmacological actions using hotplate and tail immersion method and acetic acid-induced writhing test in mice respectively. The hydromethanol extract was also investigated for its antioxidant action using 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, Nitric Oxide (NO) scavenging and reducing power assays. Results: The extract, at the dose of 250 and 500 mg kg-1, produced a significant (p<0.05) increase in pain threshold in hotplate and tail immersion methods in a dose dependent manner. In acetic acid-induced writhing test, the extract (500 mg kg-1) produced a maximum of 53.73% inhibition (p<0.001) of writhing reaction compared to the reference drug Diclofenac-Na (76%). A dose dependent scavenging of DPPH radical and NO was observed with good reducing power with the extract. In DPPH radical scavenging assay, the IC50 value of the extract was 375.40 μg mL-1 while the IC50 value for the reference ascorbic acid was 55.89 μg mL-1. The IC50 values of the extract and ascorbic acid were 220.43 and 125.10 μg mL-1, respectively in NO scavenging assay. Conclusion: The findings of the study suggested that the extract from Mikania scandens has strong analgesic and antioxidant effects.
  S.M. Raquibul Hasan , M.M. Hossain , R. Akter , M. Jamila , M.E.H. Mazumder , M.A. Alam , A. Faruque , S. Rana and S. Rahman
  Analgesic potential of the pet ether (PECB), chloroform (CCB), n-butanol (NBCB) and hydromethanolic (HMCB) fractions of the aerial parts of Commelina benghalensis Linn. was evaluated for centrally acting analgesic property using hotplate and tail immersion method and peripheral pharmacological actions using acetic acid-induced writhing test to scientifically validate some of the folkloric and ethnomedical uses of the plant. All fractions, at the dose of 200 and 400 mg kg-1 b.wt., displayed significant analgesic action in a dose dependent manner in the tested models. In acetic acid-induced writhing test, all extracts exhibited significant (p<0.05) reduction of writhing response in a dose dependent manner; the response decreased in the order Diclofenac-Na (76.16%) > CCB2 (68.8%) > NBCB2 (61.9%) > HMCB2 (52.8%) > PECB2 (48.0%). In hotplate and tail immersion method, all fractions caused a significant (p<0.0-0.001) increase in latency time and the results are comparable to the standard drug Nalbuphine. These results suggest significant analgesic potential of C. benghalensis and thereby justify its traditional uses in various types of pain.
 
 
 
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