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Articles by S.K. Yadav
Total Records ( 3 ) for S.K. Yadav
  A.N. Aher , S.C. Pal , S.K. Yadav , U.K. Patil and S. Bhattacharya
  The aim of the present study was to isolate the active constituents responsible for antioxidant activity. Radical scavenging activities of chromatographically isolated compounds from methanolic extracts of wood, bark, fruit and leaf were measured by the 1, 1-Diphenyl-2- Picrylhydrazyl (DPPH) method. The structures of isolated compounds were confirmed by spectroscopic techniques comprising of UV, IR, 13C NMR, P-NMR, Mass spectral and Co-TLC studies. The compound ANA 01, ANA 02 and ANA 04 were isolated from bark and confirmed as catechin, ellagic acid and gallic acid, respectively. The leaf extract resulted in separation of compounds ANA 03 (quercetin). The free radical scavenging activity of the different isolated compounds from methanolic extracts of Casuarina equisetifolia increased in a concentration dependent manner. ANA 04 (gallic acid) exhibited very strong antioxidant activity and when compared to ANA 01 (catechin), ANA02 (ellagic acid), ANA 03 (quercetin) and ANA05 (lupeol). This study suggests that the Casuarina equisetifolia could be pharmaceutically exploited for antioxidant properties.
  S.K. Yadav , P. Pandey , B. Kumar and B.G. Suresh
  This study has been conducted to determine the extent of genetic association between yield of Rice (Oryza sativa L.) and its components. The present experiment was carried out with 40 Rice (Oryza sativa L.) genotypes which were evaluated in a randomized block design with 3 replications during wet season of 2007 and 2008. Results showed that sufficient amount of variability was found in the entire gene pool for all traits studied. Higher magnitude of genotypic and phenotypic coefficients of variation was recorded for seed yield, harvest index, biological yield, number of spikelets per panicle, flag leaf length, plant height and number of tillers indicates that these characters are least influence by environment. High heritability coupled with high genetic advance as percent of mean was registered for seed yield, harvest index, number of spikelets per panicle, biological yield and flag leaf length, suggesting preponderance of additive gene action in the expression of these characters. Grain yield was significantly and positively associated with harvest index, number of tillers per hill, number of panicle per plant, panicle length, number of spikelet's per panicle and test weight at both genotypic and phenotypic levels. Path coefficient analysis revealed that harvest index, biological yield, number of tillers per hill, panicle length, number of spikelets per panicle, plant height and test weight had direct positive effect on seed yield, indicating these are the main contributors to yield. From this study it may be concluded that harvest index, number of tillers per hill, panicle length and number of spikelet per panicle and test weight are the most important characters that contributed directly to yield. Thus, these characters may serve selection criteria for improving genetic potential of rice.
  A. Kumari , V. Kumar and S.K. Yadav
  Natural product isolation and extraction is full of many technical hitches. In spite of that plant origin natural products have occupied lead positions as drugs in current pharmacopoeia. In this article, problems in natural product drug development and the possibilities of their improvement through nanoformulations using nanotechnology have been reviewed. Known effects and no side effects have made natural products a powerful therapeutic solution to the organisms. But the delivery of plant origin therapeutic molecules as drugs is problematic due to poor solubility, poor permeability, low bioavailability, instability in biological milieu and extensive first pass metabolism. These limitations of plant origin drugs can be overcome by attaching or encapsulating them with suitable nanomaterials. Nanomaterials can significantly enhance the pharmacokinetics and therapeutic index of plant origin drugs. Targeted delivery and combination therapy can drastically improve the performance of plant origin drugs.
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