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Articles by S.K. Mishra
Total Records ( 7 ) for S.K. Mishra
  P. Mohapatra , R.K. Swain , S.K. Mishra , T. Behera , P. Swain , N.C. Behura , G. Sahoo , K. Sethy , B.P. Bhol and K. Dhama
  To study the comparative effects of Nano Selenium (Nano-Se) and sodium selenite on the growth, bioavailability, antioxidative activities, hematological and biochemical parameters, cellular and humoral immunity, a trial was conducted on BV 300 layer birds during grower phase (9-20 after weeks) in six treated groups. After twenth weeks body weight of the all Nano-Se treated groups (up to a dose of 0.3 mg kg-1 of diet) was found to be significantly (p<0.05) higher than sodium selenite treated and control groups. However, further increase in dietary Nano-Se content in feed had negative effect on body weight of bird. Birds fed with both Nano-Se and sodium selenite showed higher (p<0.05) Se content in different tissues (Such as breast muscle, liver, kidney, pancreas, serum and feathers). However, Se content in liver, breast muscle, pancrease and feathers were signifcantly higher (p<0.05) in Nano-Se treated groups. In addition, significant (p<0.05) difference was observed as regard to glutathione peroxidase (GSH-Px), erythrocyte catalase (CAT) and superoxide dismutase (SOD) activities among the treated groups. Significantly better cellular and humoral immunity response were observed in Se supplemented birds. Dietary supplementation of Nano-Se improved the body weight, feed consumption ratio, antioxidant status, immunity and tissue Se deposition in grower birds.
  P. Mohapatra , R.K. Swain , S.K. Mishra , T. Behera , P. Swain , S.S. Mishra , N.C. Behura , S.C. Sabat , K. Sethy , K. Dhama and P. Jayasankar
  Comparative study on the effect of nano selenium (nano-Se) and sodium selenite on the growth, bioavailability, antioxidative activities, hematological and biochemical parameters, cellular and humoral immunity was done in layer chicks upto 8th week post feeding. The results showed significant differences (p<0.05) in relative weight gain and final body weight of the nano-Se treated groups upto a dose of 0.3 mg kg-1 of diet as compared to sodium selenite and control groups. However, further increase in dietary nano-Se content in feed had negative effect on weight and Relative Gain Rate (RGR). Survival rate and Feed Conversion Ratio (FCR) were not affected by dietary treatments. Chicks fed with both nano-Se and sodium selenite showed higher (p<0.05) Se content in different tissues (breast muscle, liver, kidney, pancreas, serum and feathers). However, highest value (p<0.05) of Se content in breast muscle and liver was observed in nano-Se treated groups. Selenium concentrations in serum, liver and breast muscle increased linearly and quadratically (p<0.05) as dietary Se level increased for all Se sources but its magnitude was substantially greater (p<0.05) when nano-Se was fed. Glutathione peroxidase (GSH-Px), erythrocyte catalase (CAT) and superoxide dismutase (SOD) activities were significantly different (p<0.05) in all treated groups than control. Dietary nano-Se also increased several serum biochemical and haematological parameters. In addition, it significantly increased both cellular and humoral immunity in layer chicks after 8th weeks of post feeding. In conclusion, dietary administration of nano-Se was found superior than that of inorganic sodium selenite in various aspects in layer chicks. Further extensive study for exploring absorption mechanisms, metabolic pathways, ideal dose/form of nano-Se is suggested for optimum utilization of nano-material based application of Se feeding in poultry.
  A. Das , S.K. Mishra , R.K. Swain , G. Sahoo , N.C. Behura , K. Sethi , B. Chichilichi , S.R. Mishra , T. Behera , K. Dhama and P. Swain
  A comparative study on effect of replacement of inorganic minerals viz., Zinc (Zn), Copper (Cu) and Manganese (Mn) with their corresponding organic minerals (methionine) on growth, bioavailability and immunity in layer chicks was undertaken till 8th week post feeding. At 8th week, the body weight of birds were found to be significantly (p<0.05) higher in 100% organic Zn group, 100 and 50% organic Zn, Cu and Mn supplemented groups. The cumulative feed consumption and Feed Conversion Ratio (FCR) of all the treated groups showed no significant (p>0.05) difference. The serum glucose, cholesterol and ALP levels showed significant (p<0.05) differences. Significantly (p<0.05) higher titer levels were observed in 100% organic Zn group, 100% and 50% organic Zn, Cu and Mn supplementation groups. The CBH response of all the treated groups showed no significant (p>0.05) difference. At 8 weeks of age, the relative weight of spleen of layer chicks in 100% and 50% organic Zn, Cu and Mn supplementation groups were significantly (p<0.05) higher than all the other treatments. Tibia bone weight (g), tibia calcium (%) and tibia phosphorus (%) varied insignificantly (p>0.05). But significant (p<0.05) difference was observed with respect to the tibia ash content. Except Zn and Mn levels of tibia, all other studied mineral levels of serum and liver did not differ significantly (p>0.05). Faecal excretions of minerals were significantly lower in organic mineral fed groups. Replacement of inorganic Zn, Cu and Mn with corresponding organic minerals improved the body weight, immunity and lower faecal excretion of minerals in chicks.
  Abinash Das , S.K. Mishra , R.K. Swain , P. Swain , K. Dhama , G. Sahoo , N.C. Behura , K. Sethy , B. Chichilichi , T. Behera and S.R. Mishra
  Effect of replacement of inorganic minerals viz., zinc (Zn), copper (Cu) and manganese (Mn) with their corresponding organic minerals (methionine) on growth, bioavailability and immunity was studied in grower birds (9th to 20th week). At 20th week, the body weight of grower birds were significantly (p<0.05) higher in 100% organic Zn group, 100 and 50% organic Zn, Cu and Mn supplemented groups. The cumulative feed consumption and FCR of all the treated groups showed no significant (p>0.05) difference. The serum glucose, after cholesterol SGOT, SGPT and ALP levels differ significantly (p<0.05) of all the treated groups of differed significantly (p<0.05). The CBH response and the antibody titers against SRBC were found to be significantly higher in 100% organic Zn group and 100% Zn, Cu and Mn supplemented groups. Tibia bone weight (g), tibia calcium (%) and tibia phosphorus (%) varied insignificantly (p>0.05). But significant (p<0.05) difference was observed as regard to the tibia ash content. Faecal excretions of Zn, Cu and Mn were significantly lower in organic mineral fed groups. Replacement of inorganic Zn, Cu and Mn with their corresponding organic minerals improved the body weight and immunity, with lower faecal excretion of minerals in grower birds.
  R.N. Chatterjee , R.P. Sharma , B.L.N. Reddy , M. Niranjan , Shivaprasad and S.K. Mishra
  The data of G-5 generation of inbred and non-inbred populations of Dahlem Red were utilized in the present study. These populations were originally developed by a regular system of full sib and half sib mating for 5 successive generations. A random mated non-inbred population was also maintained. Consequently, 3 sub populations have been developed from the same base population, namely, a full sib mated group (FS), a half sib mated group (HS) and a non-inbred group (NB). The inbreeding coefficient in the G-5 generation in the FS group and HS groups was 67.2% and 44.9%, respectively. These three sub populations were subjected to PCR-RAPD analysis to observe the genetic distance and similarity between different subpopulations. A total of 41 random primers (decamers) were screened for RAPD analysis, out of which 21 primers amplified the genomic DNA, generated 128 to 4544 bp bands. The Mean Average Percentage Difference (MAPD) varied between 13.22 and 22.20. The MAPD was highest between FS and NB and lowest between HS and FS. The intra-population genetic similarity was highest in FS (0.7139) followed by HS (0.7095) and NB (0.7054) which indicated that FS subpopulation is most uniform. The FS and NB had maximum genetic distance (by both band sharing and band frequency) and FS and HS had lowest genetic distance. The immune response to SRBC was highest in NB group followed by FS and HS groups.
  S.K. Mishra , P.N. Singh and S.D. Dubey
  The dried ethanolic extract of the root of Capparis zeylanica Lin. (Capparidaceae) was assessed for effect on the Central Nervous System (CNS) using a number of neuropharmacological experimental models in mice. The extract (EECZ) on mice were tested in several animal paradigms, including sodium pentobarbital-induced sleep, open field tests and hole-cross tests. Mice acutely treated with ethanolic extract of Capparis zeylanica (EECZ) at 100, 200 and 400 mg kg-1 doses prolonged the sleeping time induced by pentobarbitone (40 mg kg-1). This extract, at 100 and 200 mg kg-1 doses, showed a sedative effect in the hole-cross paradigm and decreased spontaneous activity in mice. The EECZ treatment did not produced mortality up to 2000 mg kg-1. Chemical analysis showed that the EECZ alkaloids, steroids, phytosterol, fatty acids, phenols, flavonoids, flavonols, tannins and mucilage are the main compounds of the active extract. The extract produced a dose-dependent reduction of the onset and duration of pentobarbitone induced hypnosis, reduction of locomotor and exploratory activities in the open field, hole-cross tests etc. At the same dose levels, the ethanolic extract of Capparis zeylanica (EECZ) root dose-dependently inhibited acetic acid-induced writhing in mice. The mechanism of this depression is not clearly understood at this point but it can be assumed that the drug may exert CNS depressant effect by interfering with the function of cortex. The results have suggested that the crude hydroalcholic extract of Capparis zeylanica root possesses some biologically active constituents with sedative activities.
  S.K. Mishra , P.N. Singh and S.D. Dubey
  The phytochemical screening reveals the presence of phenol, tannins, flavonoids, fatty acids, saponins etc. in ethanolic extracts of Capparis zeylanica root which was confirmed by the used of various reagents and TLC chromatography. The aim of this study was to evaluate the effects of the ethanol extract of Capparis zeylanica roots (EECZ) in animal models of epilepsy. The ethanolic extract of Capparis zeylanica Linn. (EECZ) was subjected to acute toxicity and then screened for anticonvulsant activity on Maximal Electroshock (MES) and Pentylenete Trazole (PTZ) induced seizures models in albino wistar rats. The extract was found non toxic up to the recommended dose 2000 mg kg-1 body weight orally as per OECD guidelines No. 423. For the acute study, in the maximal electroshock seizure model, the administration of 100 mg kg-1 of EECZ resulted in the complete abolition of seizures in 33.65% of the rats and this was increased to 82.51% with the administration of 400 mg kg-1. In the pentylenetetrazole-induced seizure model, 20% protection from mortality was obtained by administration of 100 mg kg-1 and 36% from 200 mg kg-1 EECZ whereas, 80% rats were protected with the administration of 400 mg kg-1. For the chronic study, in the maximal electroshock seizure model, the administration of 100 mg kg-1 EECZ resulted in the complete abolition of seizures in 12.76% of the mice and in 80%, with the administration of 400 mg kg-1. In the pentylenetetrazole-induced seizure model, 15% of the mice were protected from mortality with 100 mg kg-1 EECZ and 85%, with 400 mg kg-1 EECZ. These findings indicate that EECZ consists of anticonvulsant effect and is comparable to clinically used antiepileptic drugs (Diazepam and Phenytoin).
 
 
 
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