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Articles by S.K. Garg
Total Records ( 2 ) for S.K. Garg
  Arvind Kumar , Anu Rahal , Ram Ragvendra , Atul Prakash , Rajesh Mandil and S.K. Garg
  Levofloxacin is a third generation fluoroquinolone with excellent tissue penetration and efficacy against respiratory and urogenital bacterial infections. In the present study, disposition kinetics of levofloxacin was studied in cattle calves following an intravenous (i.v.) and intramuscular (i.m.) administration at a dose rate of 10 mg kg-1. Blood was collected at predetermined time intervals and plasma was separated. Plasma concentrations of levofloxacin were determined using the HPLC assay method (R2 = 0.999). Plasma concentration versus time data was subjected to compartmental pharmacokinetic analysis using nonlinear iterative computer software “PHARMKIT”. Following intravenous and intramuscular administration of levofloxacin in cattle calves (10 mg kg-1), the plasma concentration versus time data of levofloxacin was best described by two-compartment open model and one-compartment open model with first order absorption rate constant with modest bioavailability values, respectively. The mean values for t½α and t½β were 0.05±0.01 h and 2.12±0.21 h, respectively for i.v. route. The values of AUC, Vdarea and ClB were found to be 29.32±1.19 μg mL-1 h, 1.05±0.10 L kg-1 and 0.34±0.01 L h-1 kg-1, respectively while the ratio of drug concentrations between the tissues and plasma (T/P) was 4.47±02.09. For i.m. route, the mean (±SE) values of t1/2Ka, t½β, AUC, MAT, MRT and F were found to be 0.51±0.09 h, 2.76±0.36 h, 18.43±2.15 μg mL-1 h, 1.85±0.46 h, 4.72±0.72 h and 62.65±5.99%, respectively. Based on the pharmacodynamic indices, the optimal dose of levofloxacin in cattle calves may be proposed as 10 mg kg-1 b.wt. repeated at 24 h interval preferably by intravenous route for treating common microbial infections of veterinary importance.
  M. Tripathi and S.K. Garg
  Bioremediation is being viewed as a clean technology for decontamination of pentachlorophenol and chromium from tannery effluent. This study was conducted to isolate an efficient bacterial culture from treated tannery effluent which is tolerant to pentachlorophenol and Cr (VI) and could be employed for simultaneous bioremediation of both the toxic contaminants. Tannery effluent sample was collected from Common Effluent Treatment Plant, Kanpur (India). Fifty four bacterial cultures isolated by enrichment culture technique were screened for PCP and Cr (VI) tolerance on minimal salt medium supplemented with glucose as a cometabolite. The isolate B4 was found to be maximally tolerant to high concentration of both pentachlorophenol (500 mg L-1) and chromium (VI) (200 mg L-1) and was selected for further studies. It was identified as Bacillus sp. by morphological and biochemical analyses. The effect of various growth parameters such as carbon source at 0.2-1.0% (glucose, maltose, sucrose), pH (6.5-8.0), temperature (25-40°C) and inoculum size (0.5-2.5% v/v) were evaluated in minimal salt medium supplemented with 500 mg L-1 PCP and 200 mg L-1 Cr (VI). The best growth was exhibited at 0.4 % glucose, pH 7.0, 35°C and with 1.0% inoculum under shaking at 150 rpm. Thus, our isolate appears to have great potential for simultaneous bioremediation of pentachlorophenol and hexavalent chromium from the contaminated sites.
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