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Articles by S.K. Basu
Total Records ( 3 ) for S.K. Basu
  M.O. Aremu , B.G. Osinfade , S.K. Basu and B.E. Ablaku
  Ogi is a maize product and a popular starchy porridge in the west coasts of Africa. Although consumed by adults as a breakfast cereal, its main use is as weaning food for infants. In this study, the nutritional quality of ogi from a composite mixture of maize (Zea mays L.) and kersting’s groundnut (Kerstingiella geocarpa L.) flours was evaluated using standard processing techniques. Maize flour was substituted with kersting’s groundnut seed flour at ratios of 90:10, 80:20, 70:30 and 60:40 maize: kersting’s groundnut; with 100% maize ogi flour as control. The results showed that protein and fat contents increased with increased kersting’s groundnut seed flour substitution, reaching 61.14 and 14.63% dry weight, respectively at 60:40 ratios. All the macro-minerals (Ca, P, Mg, K and Na) analyzed for also recorded increased concentrations in the ogi flours with increased kersting’s groundnut seed substitutions. Harmful heavy metals such as lead and cadmium were not detected. The Total Essential Amino Acids (TEAA) ranged from 26.4-32.6 g/100 g crude protein or from 47.9-48.4% of The Total Amino Acid (TAA) while the Limiting Amino Acid (LAA) for all the samples was Met+Cys based on the provisional FAO/WHO standards. Generally, the present study indicates that at = 30% Kerstingiella geocarpa seed substitution ogi can be maintained, with higher nutrient content.
  S.K. Basu , M. Rupeshkumar and K. Kavitha
  The purpose of this investigation was to study the anti-inflammatory, analgesic and anti-pyretic properties of total extract and three fractions (ether, chloroform and ethyl acetate) from Andrographis echioides (Acanthaceae) in rats and mice. The plant material was extracted with methanol. In order to estimate the polarity of the active compounds, the total extract was successively partitioned between ether, chloroform and ethyl acetate. Dose of 200 and 400 mg kg-1 of each extracts were used in carrageenan-induced paw edema, cotton-pellet granuloma in rats, writhing nociception in mice and yeast induced hyperpyrexia in rats. All compounds reduced paw edema in comparison to the control group at 5 h post carrageenan injection. The total, ether and ethyl acetate extracts were similar to phenylbutazone (p<0.001), while the chloroform extract was weaker than phenyl butazone in reduction of paw edema and cotton-pellet granuloma. All extracts as well as Paracetamol induced antinociception in writhing test in comparison to control. Positive results for flavanoids and phenolic compounds were investigated by phytochemical analysis of total extract. Phenolic compounds were found in three fractions. The higher antinociception effects of total and ether extracts among different extracts tested, might back to the presence of flavanoids and phenolic compounds. The total, ether, ethyl acetate extract produced a significant dose dependent inhibition of temperature elevation. These data suggest that different extracts of A. echioides produce antinociceptive, anti-inflammatory and anti-pyretic activities that could be due to the effect of one or a combination of the bio active components in each extract.
  S.K. Basu , M. Rupeshkumar and K. Kavitha
  In this study, the methanolic extract of Andrographis echioides (MEAE) was investigated for its hepatoprotective and antioxidant effects against acetaminophen induced hepatotoxicity in Wistar albino rats. The plant extract (200 and 400 mg kg-1, p.o./day for 10 days) showed a remarkable hepatoprotective and antioxidant activity. Hepatotoxicity was induced by acetaminophen at the dose of 750 mg kg-1 p.o. for 10 days. The serum marker enzymes such as aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphates (ALP), total bilirubin and liver gamma glutamate transpeptidase (GGTP), lipid peroxidase (LPO) were significantly increased with a reduction of liver total protein, superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and glutathione-S-transferase (GST) in acetaminophen induced rats. Treatment of rats with different doses of plant extract (200 and 400 mg kg-1, p.o.) significantly (p<0.001) altered serum marker enzymes and antioxidant levels to near normal against acetaminophen-treated rats. The activity of the extract at the different dose was comparable to the standard drug, silymarin (50 mg kg-1, p.o.). Extensive vascular degenerative changes and centrilobular necrosis in hepatocytes was produced by acetaminophen. Treatment with different doses of aerial parts of methanol extract of A. echioides produced only mild degenerative changes and absence of centrilobular necrosis, indicating its hepatoprotective efficiency. Results indicate that A. echioides possesses hepatoprotective and antioxidant effects against acetaminophen induced hepatotoxicity in rats. Thus, the study substantiates the hepatoprotective and antioxidant potential of methanol extract of A. echioides.
 
 
 
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