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Articles by S.H. Garba
Total Records ( 2 ) for S.H. Garba
  S.H. Garba , J. Prasad and U.K. Sandabe
  The aqueous root-bark extract of Ficus sycomorus (Linn) was screened for its chemical constituents, median lethal dose and its histomorphological effect on the liver and kidney of albino rats. A total of 114 adult albino rats of both sexes weighing between 150-320 g were used in this study. The animals were weighed and randomly divided into two batches for the acute toxicity and histomorphological studies. In the acute toxicity study the aqueous extract of the root-bark of Ficus sycomorus was administered intraperitoneally (ip) in a dose range of 0.2-12 g kg-1 and the rats were observed for the physical signs of toxicity for 24 h. For the histomorphological effect of the extract on the liver and kidney 320, 640 and 1,280 mg kg-1 were administered to the rats for 2, 4 and 6 weeks, respectively. At the end of each treatment period, the animals were weighed before been sacrificed and the liver and kidneys were extracted, weighed and processed for histological assessment. Phytochemical screening of the extract showed the presence of saponins, flavonoids, alkaloids, tannins and reducing sugar while the median lethal dose (LD50 ) was calculated as 3.20±0.60 g kg-1. A significant decrease (p<0. 001) in body weight was observed but weights of kidney and liver treated with the extract were not affected significantly. Microscopic examination of the liver tissues of rats treated with the extract showed degenerative changes ranging from cytoplasmic vacuolation of hepatocytes, necrosis, dilatation of the central vein and proliferation of bile ducts. There was no observable effect on the kidney. The results of the study suggest that the extract possess hepatotoxic potentials and should be used with caution but a further research to assess the pharmacokinetics of the extract on cell membrane stability, lipid peroxidation, parenchymal cell regeneration and ultra structural study will be useful and is recommended.
  A.U. Ekanem , S.H. Garba and A.G. Jankada
  The effect of Aspirin (ASA) and indomethacin (Indocin) on the histomorphology of the female reproductive organs was investigated. A total of 60 female albino rats of the Wister Strain were randomly divided into 12 groups of 5 rats each (group’s 1-12). Groups 1 and 2 served as the control groups and were administered normal saline and dimethylsulfoxide (DMSO 5 mg kg-1 body weight), respectively for 14 days. Groups 3-7 were administered 10, 25, 50, 75 and 100 mg kg-1 body weight of aspirin respectively for 14 days while groups 8-12 received 2.0, 2.5, 3.0, 3.5 and 4.0 mg kg-1 body weight of indomethacin respectively for 14 days. At the end of the 14 day, the animals were sacrificed and the ovary, uterine tubes and uterus obtained for routine histological processing and subsequent histopathological assessment. Results from this study showed normal histological profiles of all organs obtained from the rats in the control groups while the experimental groups treated with aspirin and indomethacin presented with vasoconstriction in the ovary and atrophy of smooth muscles of the uterine tubes and uterus. This study has establish to some extent, the vasoconstrictive potency of aspirin and indomethacin and thus providing an experimental basis for the use of these drugs to reduce and if possible stop ovarian and uterine hemorrhage but further investigation to elucidate the vasoconstrictory effect, smooth muscle atrophy and the reversibility of some of the toxic effect of these drugs on the female reproductive organs and the mechanism involved is recommended in further studies.
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