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Articles by S.B. Olaleye
Total Records ( 5 ) for S.B. Olaleye
  K.O. Ajeigbe , E.O. Nwobodo , T.O. Oyesola , D.A. Ofusori and S.B. Olaleye
  The aim of this study was to investigate the effect of Chloroquine phosphate (at therapeutic dose) on existing gastric ulceration in albino rats. Rats were treated with Chloroquine phosphate (8.5 mg kg-1) intramuscularly for 24 h after formation of ulcers induced by acidified ethanol and indomethacin. Following sacrifice, colorimetric assays were applied to determine the concentration of protein and mucus, activities of catalase and lipid peroxidation in homogenized gastric mucosal samples. Chloroquine phosphate worsens gastric lesions produced by both indomethacin and acidified ethanol. Also, it seemed to elaborate the indomethacin and acidified ethanol induced effects on gastric juice volume, pH and acid output. On the other hand, thiobarbituric acid reactants (TBAR) was further increased and protein, catalase and mucus were decreased in the gastric mucosal samples. The data indicates that the use of Chloroquine may be dangerous to the integrity of the stomach, especially in existing gastric ulcers. It increases oxidative stress in the gastric mucosa caused by indomethacin and acidified ethanol.
  Y. Raji , Olufadekemi T. Kunle-Alabi , S.B. Olaleye , M.A. Gbadegesin , F.O. Awobajo , O.A. Osonuga , A.O Odukanmi , S.A Salami and Adeyombo F. Bolarinwa
  Antimicrobial drugs have been reported to have adverse effects on male fertility. The present study reports the role of α- tocopherol on metronidazole and tetracycline induced reproductive alterations in albino rats. Male albino rats (5/group) were treated with 20 mg kg-1 bw day-1 metronidazole or 60 mg kg-1 day-1 tetracycline with or without 15 mg kg-1 bw α-tocopherol for 8 weeks. The reversibility of effects after 4 weeks recovery period was determined in separate groups of 5 rats. The control groups received distilled water (vehicle) and 15 mg kg-1 day-1 α- tocopherol for 8 weeks. Metronidazole and tetracycline significantly (p<0.05) reduced the weight of the epididymis, sperm count, motility and serum testosterone levels and increased the activity of endogenous superoxide dismutase (SOD) in the testis. Alpha-tocopherol significantly (p<0.05) decreased the weight of the testis, epididymis, sperm motility and serum testosterone levels. Co-administration of metronidazole or tetracycline with α-tocopherol caused significant restoration in sperm indices and SOD activity while it produced no effect on testosterone secretion. The results suggest that the effects of metronidazole and tetracycline on male reproductive functions, which are partially reversible, could be mediated via a reduction in serum testosterone level and probably also via the free radical generating mechanism.
  S.B. Olaleye and K.O. Ajeigbe
  The aim of the present study was to investigate the effect of the therapeutic dose of sulfadoxine-pyrimethamine on experimentally induced gastric ulceration in albino rats. Rats were given sulfadoxine-pyrimethamine (22.5 mg kg-1) intramuscularly for 24 h after formation of ulcers induced by indomethacin or by acidified ethanol. Upon sacrifice, colorimetric assays were applied to determine the concentration of protein and mucus, activities of catalase and superoxide dismutase and lipid peroxidation in homogenized gastric mucosal samples. Sulfadoxine-pyrimethamine was observed to alleviate gastric lesions produced either by indomethacin or acidified ethanol. Also, the drug seemed to attenuate the indomethacin or acidified ethanol induced effects on gastric juice volume, pH and acid output. On the other hand, thiobarbituric acid reactants (TBAR) was decreased and superoxide dismutase (SOD) and catalase (CAT) activities increased in the gastric mucosal samples, though, however, protein and mucus concentrations remained statistically unchanged. The use of sulfadoxine-pyrimethamine may be safe on the integrity of the stomach, especially in existing gastric ulcers. It ameliorates oxidative stress in the gastric mucosa caused by indomethacin and acidified ethanol.
  S.F. Ige , R.E. Akhigbe , A.A. Adewale , J.A. Badmus , S.B. Olaleye , F.O. Ajao , W.A. Saka and O.Q. Owolabi
  This study aims at investigating the effect of pre-treatment, co-treatment and post-treatment with Allium cepa extract, AcE, on cadmium-induced renal toxicity and confirming possible mechanisms by which Allium cepa extract reduce/restore cadmium induces nephrotoxicity. Thirty male Sprague Dawley rats were used. They were divided into 5 groups (n = 6). Group 1 was used as control. Group 2 was intraperitoneally administered 1.5 mL kg-1 BW of 0.3 mg L-1 of cadmium sulphate for 3 days. Group 3 was pretreated with 1.0 mL kg-1 BW of AcE for 8 weeks followed by intraperitoneal administration of 1.5 mL kg-1 b.wt. of 0.3 mg L-1 of cadmium sulphate. Group 4 was co-treated with 1.5 mL kg-1 BW of 0.3 mg L-1 of cadmium sulphate for 3 days and 1.0 mL kg-1 BW of AcE for 8 weeks simultaneously. Group 5 was post-treated with 1.0 mL kg-1 BW of cadmium sulphate for 8 weeks following a 3 day course of 1.5 mL kg-1 BW of 0.3 mg L-1 of cadmium sulphate intraperitoneal administration. All groups were allowed free access to standard rat chow and water throughout the period of experiment. After the experiment period, rats were sacrificed by cervical dislocation and blood sample were obtained via cardiac puncture. The kidneys were also excised. Changes in body and kidney weights were determined. Renal weight index, 24 h urine volume, renal clearance and lipid peroxidation status were also determined. There was no significant change in body and kidney weight and renal weight index in all groups. Renal clearance and 24 h urine volume were significantly reduced in group 2 rats when compared to all groups. Renal clearance was also reduced in group 3 and 5, though this decrease was only significant when compared with the control group. Plasma and tissue SOD activities were significantly increased in group 2. Plasma and tissue MDA levels were significantly increased in group 2, 3 and 5. This study shows that cadmium induces nephrotoxicity by impairing renal functions and stimulating lipid peroxidation. Pre-treatment and post-treatment of AcE in cadmium-treated rats produced mild protective potentials. However, co-treatment with AcE during cadmium administration showed significant antioxidative potentials in preventing cadmium-induced nephrotoxicity.
  K.O. Ajeigbe , S.B. Olaleye and E.O. Nwobodo
  In this study, the effects of two antimalarials-amodiaquine hydrochloride and artemisinin were investigated in ulcerated albino rats of Wistar strain. Rats were treated with amodiaquine (30 mg kg-1) and Artemisinin (2.86 mg kg-1) for 24 h after formation of ulcers induced by indomethacin. Treatments with Amodiaquine Hydrochloride led to significantly increased gastric lesions while artemisinin led to significantly decreased gastric lesions. Also, amodiaquine hydrochloride seemed to elaborate the indomethacin induced effects on gastric juice volume, pH and acid output, while artemisinin attenuated these changes. The data indicates that the use of amodiaquine hydrochloride may be dangerous to the integrity of the stomach, especially in existing gastric ulcers, while artemisinin is mild and ameliorating, may result from their lipid peroxidation/apoptosis activity interference.
 
 
 
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