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Articles by S.B. Olaleye
Total Records ( 3 ) for S.B. Olaleye
  B.A. Adeniyi , R.O. Odufowoke and S.B. Olaleye
  The antibacterial and gastroprotective properties of crude extracts of Eucalyptus torelliana were investigated. Antibacterial activity was investigated by screening the crude extracts for activity against clinically isolated strains of wound bacteria viz., Staphylococcus aureus UCH 2010, Pseudomonas aeruginosa UCH 2125, Escherichia coli UCH 2007, Klebsiella species UCH 2694 and Proteus mirabilis CHO 2014. The dichloromethane crude extracts demonstrated highest antibacterial activity against all tested microorganisms at 10 mg mL-1 concentration. The gastroprotective effect of the crude extract of the leaf was investigated in albino rats. This was evaluated against gastric mucosal damage induced by ethanol/HCl mixture. Ethanol/HCl mixture (1.5 mL of 0.15 N HCl in 70% ethanol) caused severe gastric mucosal damage with ulcer index of 2.7±0.33. Pre-treatment of animals with crude extract of Eucalyptus torelliana leaf 200 and 1000 mg kg-1 orally for 1h significantly reduced the Pre-treatment of animals with 50 mg kg -1. Ranitidine for 1 h reduced the reduced the formation of ulcer by the ethanol HCl mixture with preventive ratios 56 and 92.5%, respectively. Ranitidine (50 mg kg-1) afforded 92.5% protection. The results therefore suggest that crude extracts of Eucalyptus torelliana possess both antibacterial and gastroprotective properties.
  B.A. Adeniyi , T.O. Lawal and S.B. Olaleye
  The crude extracts of Eucalyptus camaldulensis were investigated for their in vitro antimicrobial and gastro-protective activities in albino rats. The antimicrobial activity was investigated by screening the crude plant extract for activity against Candida albicans and clinically isolated gentamycin resistant wound bacteria viz: Staphylococcus aureus UCH 2600, Escherichia coli UCH 2554, Pseudomonas aeruginosa UCH 2780 and Proteus mirabilis UCH 2773. These microorganisms were susceptible to the crude extracts at a 10 mg mL-1 concentration. The gastroprotective activity of the methanol extract of Eucalyptus camaldulensis (MEEC) was investigated in rats. Gastro protection was evaluated against gastric mucosal damage induced by ethanol/HCl mixture. The Hcl/Ethanol mixture (1.5 mL of 0.15 N HCl in 70% ethanol) caused severe gastric damage with ulcer index 2.7±0.33. Pre-treatment of animals with crude extract of Eucalyptus camaldulensis leaf 200 and 1000 mg kg-1 orally for 1 h significantly reduced the formation of ulcer by the HCl/ethanol mixture with preventive ratios of 56 and 89%, respectively. Ranitidine afforded 92.5% protection. The results suggest that crude extracts of Eucalyptus camaldulensis has both antimicrobial and anti-ulcer properties.
  J.K. Adesanwo , Y. Raji , S.B. Olaleye , S.A. Onasanwo , O.O. Fadare , O.O. Ige and O.O. Odusanya
  The effect of Bryophyllum pinnatum leaves extract on indomethacin induced gastric ulceration was determined using 25 male albino rats. Animals were divided into 5 groups of 5 animals each. The control group received 0.5 mL of distilled water and varying doses of the extract were used for the remaining groups (10-40 mg kg-1 body weight). The result showed a significant reduction (p<0.05) in incidence of ulceration and mean basal and histamine (1 mg kg-1) stimulated gastric acid secretion in a dose dependent manner thus justifying the use of Bryophyllum pinnatum as an anti-ulcer agent in folklore medicine.
 
 
 
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