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The aim of this study was to examine the environmental
factors and selected antifungal which affect arthroconidia production
in T. verrucosum, T. violaseum, Epidermophyton floccosum,
T. rubrum and T. mentagrophytes. Arthroconidia production was
studied on different media and under conditions of varying temperature,
pH and CO2 concentrations. The effect of the addition of antifungal
to media was also examined. Arthroconidia formation was occurred optimally
on sabouraud dextrose agar under CO2 10% tension at 37°C
at pH 7.5 and was maximal at 10 days. At 42°C and in media plus NaCl
3% or more than it, no growth occurred. The rate of arthroconidia production
was different in these species. Griseofulvin, clotrimazole and betamethasone
induced the formation of arthroconidia and itraconazole and particularly
terbinafin decrease the rate of arthroconidia production. This result
emphasis to effective role of environmental factors and some of antifungals
on arthroconidia formation. Also, this result may be clinically significant,
if sufficiently fungicidal concentrations are not attained in some areas
of the lesion, the antifungal themselves may enhance the conversion of
hyphea to arthroconidia.
