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Articles by S.A. Sreenivas
Total Records ( 2 ) for S.A. Sreenivas
  V. Balamuralidhara , S.A. Sreenivas , H.V. Gangadharappa and T.M. Pramodkumar
  In the present study, an attempt was made to formulate orodispersible tablets of rabeprazole. Tablets were prepared by direct compression method using diluent and various disintegrants. Tablets were also prepared using treated agar (TAG) powder as one of the disintegrant. A total number of ten formulations were prepared and evaluated. Along with physicochemical parameters, the tablets were also evaluated for special parameters like wetting time, in vitro dispersion time, in vitro disintegration and in vitro drug release. The results of wetting time, in vitro dispersion time and in vitro disintegration signify that as the concentration of disintegrant increases the time required for disintegration decreases. A better disintegration was observed in formulation OT1, OT2, OT5 and OT6 containing crospovidone and croscarmellose sodium. The correlation and slope values obtained after performing in vitro release studies indicated that all the ten formulations followed first order release rate kinetics.
  Rajesh Mandade and S.A. Sreenivas
  Medicinal plants play a major role in the management of Diabetes mellitus especially in developing countries. The present study investigated the possible therapeutic effects of Hibiscus rosasinensis (H. rosasinensis) extract on certain biochemical markers in Streptozotocin (STZ)-induced diabetes mellitus in rats. The effects of an aqueous ethanolic extract of H. rosasinensis Aerial part on blood glucose, albumin, albumin/globulin ratio, urea, insulin, C-peptide, uric acid and creatinine and the activities of diagnostic marker enzymes aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transpeptidase were examined in the plasma, liver and kidney tissues of control and experimental groups. Oral administration of H. rosasinensis (500 mg kg-1) aqueous extract to diabetic rats for 4 weeks significantly reduced blood glucose, urea, uric acid and creatinine but increased the activities of insulin, C-peptide, albumin, albumin/globulin ratio and restored all marker enzymes to near control levels. The present results shown that H. rosasinensis extract has an antihyperglycaemic effect and consequently may alleviate liver and renal damage associated with STZ-induced diabetes mellitus in rats.
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