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Articles by S.A. Onasanwo
Total Records ( 2 ) for S.A. Onasanwo
  S.B.Olaleye , Y. Raji , S.A. Onasanwo , P. Erigbali , S.O. Oyesola , A. Odukanmi , I.O. Omotosho and R.A. Elegbe
  In the present study, the effects of long-term, low level (Lo-Pb) and high level (Hi-Pb) exposure of rats to lead on total gastric juice secretion and experimental ulceration were studied. Rats were exposed to low (0.01%; 100 ppm) or high (0.5%, 5,000 ppm, HiPb) levels of lead for a period of 15 weeks. The formation of ulcers was induced by hypothermic stress, the administration of indomethacin and the application of an HCl/Ethanol mixture. Exposure of animals to lead significantly increased gastric lesions produced by HCl/Ethanol mixture and indomethacin but not those induced by restraint stress. Both the LoPb and HiPb treatments significantly increased gastric acidity and reduced gastric juice volume. The results underscore the role of cumulative lead exposure in the aetiology of gastric ulcers in high lead areas.
  J.K. Adesanwo , Y. Raji , S.B. Olaleye , S.A. Onasanwo , O.O. Fadare , O.O. Ige and O.O. Odusanya
  The effect of Bryophyllum pinnatum leaves extract on indomethacin induced gastric ulceration was determined using 25 male albino rats. Animals were divided into 5 groups of 5 animals each. The control group received 0.5 mL of distilled water and varying doses of the extract were used for the remaining groups (10-40 mg kg-1 body weight). The result showed a significant reduction (p<0.05) in incidence of ulceration and mean basal and histamine (1 mg kg-1) stimulated gastric acid secretion in a dose dependent manner thus justifying the use of Bryophyllum pinnatum as an anti-ulcer agent in folklore medicine.
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