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Articles by S. Zhang
Total Records ( 4 ) for S. Zhang
  S. ZHANG , L.J. LONG , Y.C. ZHOU , H. YIN , Z. XIAO and Y.F. CHEN
  The effects of glycopeptides, prepared from pearl oyster Pinctada fucata, on embryonic development, larval and juvenile growth and adult non-specific immunity of P. fucata were investigated in this study. Glycopeptides had a pronounced stimulatory effect on embryonic development and larval and juvenile growth of P. fucata. enhancing with increased glycopeptide concentrations. All of haemocytes, phagocytosis, aggregation, serum microbiostatic activity and bacteriocidal activity all showed significant increases after 60-day feeding, relative to unfed controls. The major conclusion is that glycopeptides had a pronounced stimulatory effect on the non-specific immunity of pearl oysters.
  H Massaeli , J Guo , J Xu and S. Zhang
 

Rationale: The human ether-a-go-go–related gene (HERG) encodes the pore-forming subunits of the rapidly activating delayed rectifier potassium channel (IKr) that is important for cardiac repolarization. Dysfunction of HERG causes long QT syndrome (LQTS) which can lead to sudden cardiac death. We previously showed that a reduction in extracellular K+ concentration ([K+]o) prolongs QT intervals in intact rabbits, and decreases the cell surface density of IKr in rabbit ventricular myocytes and of the HERG channel expressed in human embryonic kidney (HEK) cells.

Objective: The goal of the present study was to gain insights into the mechanisms for low [K+]o induced reduction in HERG expression levels.

Methods and Results: Using patch clamp, Western blot and confocal imaging methods, we demonstrated that at low [K+]o, the HERG channel entered a novel nonconducting state. Furthermore, this novel functional state triggered rapid internalization and degradation of the cell surface HERG channels. Thus, our data demonstrated for the first time a direct link between a gating state and the plasma membrane stability of an ion channel, HERG. Using HERG-permeant cations and site-directed mutagenesis, we identified the sites in the channel which are involved in the K+o dependence of HERG channels.

Conclusions: Extracellular K+ is a prerequisite for HERG function and membrane stability.

  Yuan Dong , Zhong Xie , Baoqing Hu , Y. Huang and S. Zhang
  Study and formulate the data classification system and data standard, forming the Beibu Bay resources a standardized and environmental data system. Develop data acquisition and processing, database building and sharing technology standard, realizes data acquisition, conversion, processing, inspection, analysis, display the process sequence and sharing. According to the technical regulation, standard and integrated arrangement of Beibu Bay based data, thematic data resources environment, social and economic data and other data and information and combined with the network information technology, integrated "Guangxi Beibu Bay Economic Zone Based on the major projects" the implementation process of the acquisition, the formation of scientific data, analysis results and literature data, to establish a network of federal database, data network based on the intersection of environment, realize the network data integration; functional requirements through the analysis from the distributed environment, heterogeneous data processing, data integration and management, uncertainty, automation and intelligent and pointed out that the spatial data seamless integration is a systems engineering, need to meet the demanding requirements of in many aspects, Presents the design principle of system resources and environment in Beibu Bay seamless data integration system. A detailed analysis of the Beibu Bay resources and Environmental data system of spatial data center architecture and the general pattern, put forward the feasibility of seamless integration framework of spatial data center based on model. Research and design of system architecture for seamless integration of Beibu Bay of space data, focusing on design key components of seamless integration framework, global directory system, a multi-layer intelligent middleware etc.
  S. Zhang , M. Lynch , A.M. Gokhale and M. Liu
 

Microstructural characteristics of porous LSM/YSZ composite cathodes greatly influence the performance of solid oxide fuel cells. The triple phase boundaries, for example, account for a significant portion of the electrochemically active sites in these porous composite cathodes. Nonetheless, experimental characterization of the relevant microstructural attributes has been problematic due to lack of suitable microscopy techniques for simultaneous observations of all three phases (i.e., LSM, YSZ, and porosity) needed for identification and unbiased characterization of the triple phase boundaries. In this contribution it is shown that a combination of chemical etching and atomic force microscopy clearly reveals all three phases and the triple phase junctions in the microstructural sections. Further, stereological techniques based on the geometric probabilities of stochastic geometry enable unbiased statistical estimation of total triple phase boundary length per unit volume and other microstructural attributes from simple counting measurements performed on representative microstructural sections.

 
 
 
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