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Articles by S. Zare
Total Records ( 5 ) for S. Zare
  H. Sedghi , S. Zare , H. Hayatgeibi , S. Alivandi and A.G. Ebadi
  This study investigated the bio-effects of 50 Hz MF exposure on some Immunological factors (ACTH, cortisol and glucose levels) in male Guinea pigs. The capacity of 50 Hz Electromagnetic Fields (EMF) to interfere in the weakness of endocrine system has been a relevant fact into the scientific community, since we are more susceptible for this kind of exposure, in modern days. The 60-day-old Guinea pigs, which average of weight was 350-400 g, the Guinea pigs were divided in two groups, one of them was the control group while the other one suffered interference of a variable EMF of 50 Hz, intensity 0.207μT, 4 hours a day, for a 5 consecutive he results were collected by the weight comparison before and after of the exposure period, as well as the cortisol and glucose levels. These facts are strongly linked with the immunological system. After 5 days, the animals were anaesthetized and had their blood withdrew from their hearts. The samples produced serum where ACTH (quimiluminescent method), cortisol (radioimunoassay method) and glucose (oxidative method) levels were evaluated. The results showed that 50 Hz EMF acted on rats without any significant weight change, but affecting ACTH,cortisol and glucose levels in a significant way, 33.06% (p=0.033); 27.00% (p=0.004) and 56.23% (p=0.014) respectively when were compared with the control group. For this reason, EMF is able to change the serum levels of ACTH, cortisol and glucose, possible changing the endocrinological regulations.
  A. Afaghi , S. Zare , R. Heidari , Y. Asadpoor and R. Malekzadeh Viayeh
  The objective of this study was to evaluate the possible effects of CuSO4 exposure on variations of glucose and cortisol levels in Cyprinus carpio. Three replicates of 6 fish were subjected to two sub-lethal concentrations of CuSO4 (0.16 and 0.53 mg L-1) for 14 and 21 days. Blood samples were isolated from the fish following the exposure, to measure the levels of cortisol and glucose compared to the control group. The results showed significant increases (p<0.05) in cortisol levels for both fish groups after 14 days of exposure, whereas, the levels of blood cortisol in both groups did not differ from that of control when the fish subjected to copper sulfate for 21 days. We found significant increases (p<0.05) in the levels of blood glucose of two groups of fish after 14 days of exposure to two doses of CuSO4, as well as significant decrease in the blood glucose of both groups exposed for 21 days. In the later treatment, the rate of decrease in group II (exposed to 0.53 mg L-1 CuSO4) was higher than that of group I (exposed to 0.16 mg L-1 CuSO4) (p = 0.001 compared to p = 0.032). Our findings attest that exposing to waterborne copper would affect the levels of both cortisol and glucose, as indicators of stress response in Cyprinus carpio.
  M. Amirian , M. Rajai , A. Alavi , S. Zare and E. Aliabadi
  The objective of this study was to compare the efficiency of lidocaine with that of plain saline for paracervical pain relief during fractional curettage. The double-blind randomized clinical trial was performed on 150 patients presenting from 2004 to 2005 for curettage. The patients were assigned randomly in two groups to receive lidocaine 1% or normal saline. Number of patients at each group was 75 women. The pain intensity was assessed in four stages: 1) after speculum insertion, 2) during cervical dilatation, 3) during curettage and 4) 30 min after curettage completion. The pain intensity was graded as 0 to 100 according to the Likert Scale. The Mean±SD of pain intensity after speculum insertion, during dilatation, during curettage and 30 min after curettage in lidocaine group were 11.33±9.70, 24.93±15.36, 37.00±17.35, 6.47±6.42 and in normal saline group were 11.73±9.81, 28.20±13.19, 49.47±21.55 and 7.33±6.22, respectively. There was no significant difference between pain intensity after speculum insertion, during dilatation and during 30 min after curettage but there was a significant difference in pain intensity during curettage between lidocaine 1% group and normal saline group (p<0.05). Normal saline is as effective as lidocaine 1% in low pain in curettage (distention of nerve capsule) but when increase pain in curettage (third time point), lidocaine 1% is more effective than normal saline. Nerve capsule distention is not the only factor for pain control in paracervical block and analgesic agent is still an important factor.
  A. Eyshi Oskooii , L. Mohammad Gholizad , S. Zare and V. Nejati
  The goal of this study was to determine the effects of ABVD and ChlVPP chemotherapeutic protocols for Hodgkin's disease on the structure of testis and epididymis of male rat. After determining tolerance dose of drugs in pilot study, 24 male rats were divided to four groups: ABVD (doxorubicin, bleomycine, vinblastin, dacarbazine) group, ChlVPP (chlorambucil, vinblastin, procarbazine, prednisolone) group and two control groups one for each treatment group. One half of the lethal dose for 50% of population (LD50) was used for treatment of animals in each protocol. Testes and epididymis tissues were examined for structural changes and serum testosterone level was measured by Lission (chemiluminescence method). Body weight, testis and epididymis weights, in treated rats were significantly less than their control groups specifically in ABVD group was less than ChlVPP group. Decreasing of mean diameter of seminiferous tubules, height of spermatogenic cells and diameter of epididymis in caput, corpus and cauda in ABVD group were significantly more than ChlVPP and control group. The serum testosterone level in ABVD group was significantly less than ChlVPP and control group. According to this study results, the ChlVPP had fewer impairment effects than ABVD on testis and epididymis tissue in tolerance doses on male rats' reproductive system. More clinical trial studies are suggested on Hodgkin's patients. With equal treatment effectiveness, it will be better to use the most reliable and safe treatment especially in young patients.
  H. Sedghi , S. Zare , H. Hayatgeibi , S. Alivandi and A.G. Ebadi
  There are several reports that indicate a linkage between exposures to power frequency (50-60 Hz) magnetic fields with abnormalities in the serum biochemical parameters. The present study was designed to understand whether power frequency magnetic fields could act as an environmental insult and invoke any biochemical changes in Guinea pigs. Male Guinea pigs were randomly divided into four groups each comprising of 36 animals. Group 1 as control was found sham-exposed animals. Groups 2 to 4 exposed to 50 Hz (0.0207 μT) in three different times (1, 2 and 4 h), respectively for 5 consecutive days. We found significant decreases in the levels of total protein, β- and y-globulins and in the activities of γ-glutamyltranspeptidase and malate dehydrogenase. The activity of aspartate aminotransferase decreased, but the activity of alanine aminotransferase was unchanged. Total lipid, cholesterol, triglycerides and pre-β-lipoproteins decreased, but α-lipoproteins, glucoseand cortisol levels increased. The most pronounced changes in the biochemical parameters studied were found in workers with the longest exposure to an electromagnetic field.
 
 
 
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