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Articles by S. Vignesh
Total Records ( 2 ) for S. Vignesh
  S. Vignesh , A. Raja and R. Arthur James
  Natural product compounds are the source of numerous therapeutic agents. Recent progress to discover drugs from natural product sources has resulted in compounds that are being developed to treat cancer, resistant bacteria and viruses and immunosuppressive disorders. Many of these compounds were discovered by applying recent advances in understanding the genetics of secondary metabolism in microorganisms, exploring the marine environment and applying new screening technologies. Microbes have made a phenomenal/unique contribution to the health and well-being of people throughout the world. In addition to producing many primary metabolites, such as amino acids, vitamins and nucleotides, they are capable of making secondary metabolites, which constitute half of the pharmaceuticals on the market today (and provide agriculture with many essential products). A growing number of marine microorganisms are the sources of novel and potentially life-saving bioactive secondary metabolites. Here, we have discussed some of these novel antibacterial, antiviral, anticancer compounds isolated from marine-derived microbes and their possible roles in disease eradication and commercial exploitation of these compounds for possible drug development using many approaches.
  P. Kumarasamy , S. Vignesh , R. Arthur James , K. Muthukumar and A. Rajendran
  This study was aimed to estimate current levels of pollution indicator as well as many groups of human pathogenic bacteria and their seasonal variations in different locations of Cauvery river, South India. The samples were collected from 16 different sites along river from Stanley reservoir to estuary regions (Bay of Bengal). The microbiological scrutiny was performed during monsoon (2007), Winter, Summer and Spring (2008) seasons taken for the bacterial analysis of Total Viable Counts (TVC), Total Coliform counts (TC), Total Streptococci counts (TS) and also four different types of pathogenic bacterial load were counts, which are indicator organisms of pollution studies. Total viable counts were found in the range of 6.2-26.0 (x104) mL-1 in monsoon, 5.2-20.0 (x104) mL-1 in summer, 4.0-17.9 (x104) mL-1 in winter and 3.3-15.5 (x104) mL-1 in spring. The TC was found in the range of 4.1-21.0 (x103) mL-1, 3.6-17.0(x103) mL-1, 2.9-14.1 (x103) mL-1 and 2.3-12.0 (x103) mL-1, for TS, it was 4.3-18.0 (x102) mL-1, 3.2-13.0 (x102) mL-1, 2.6-11.0 (x102) mL-1 and 2.0-9.6 (x102) mL-1 during monsoon, summer, winter and spring, respectively. Counts of EC, SA/SH, SF and PA were in the range of 300-3700 mL-1, 20-280, 20-270 and 40-490 mL-1, respectively. The Cauvery river basin has been facing severe anthropogenic activities, mostly due to religious belief, dense population, municipal sewage and industrial waste confluences etc. A huge bacterial gene pool was obtained after this study which was indicative of immense bacterial diversity in the region.
 
 
 
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