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Articles by S. Sun
Total Records ( 6 ) for S. Sun
  K. MASAGOUNDER , J.D. FIRMAN , R.S. HAYWARD , S. SUN and P.B. BROWN
  Apparent digestibility of dry matter and energy, and availability of amino acids from blood meal (BM), fish meal (FM), meat and bone meal (MBM), poultry by-product meal (PBM), soybean meal (SBM), corn, wheat and yellow grease (YG) were determined for bluegill Lepomis macrochirus (mean weight, 57g), and likewise, but not for BM or wheat, for largemouth bass Micropterus salmoides (mean weight, 30g). To avoid nutrient interaction from a reference diet, diets containing 98.5% (985gkg−1) of test ingredients were used, except for semi-solid, YG which was mixed with corn to permit pelletization. Faeces were collected by a siphoning method. Apparent dry matter digestibility values ranged from 50% (corn) to 87% (BM) for bluegill and from 53% (MBM) to 76% (PBM) for largemouth bass. Apparent energy digestibility values ranged from 53% (corn) to 92% (BM) for bluegill and from 63% (MBM) to 93% (YG) for largemouth bass. Apparent digestibility of most amino acids exceeded 90% for evaluated protein sources, except for MBM which showed slightly lower values (80–90%) for both fishes. Isoleucine digestibility from BM was relatively low (82%) for bluegill. High digestibility values for SBM, PBM and BM, indicate good potential for replacing FM in diets for both fishes.
  Y Zhang , Y Jia , R Zheng , Y Guo , Y Wang , H Guo , M Fei and S. Sun
  BACKGROUND:

The liver is frequently subject to insult because of viral infection, alcohol abuse, or toxic chemical exposure. Extensive research has been conducted to identify blood markers that can better discern liver damage, but little progress has been achieved in clinical practice. Recently, circulating microRNAs (miRNAs) have been reported as potential biomarkers for the noninvasive diagnosis of cancer. In this study, we investigated whether plasma miRNAs have diagnostic utility in identifying liver disease.

METHODS:

The study was divided into 2 phases: marker selection by real-time quantitative PCR analysis of a small set of plasma samples, and marker validation with a large set of plasma samples from 83 patients with chronic hepatitis B viral infections, 15 patients with skeletal muscle disease, and 40 healthy controls. Two mouse model systems, d-galactosamine- and alcohol-induced liver injury, were also developed to evaluate whether differences in miRNA concentration were associated with various liver diseases.

RESULTS:

Among the miRNA candidates identified, miR-122 presented a disease severity–dependent change in plasma concentration in the patients and animal models. Compared with an increase in aminotransferase activity in the blood, the change in miR-122 concentration appeared earlier. Furthermore, this change was more specific for liver injury than for other organ damage and was more reliable, because the change was correlated with liver histologic stage.

CONCLUSIONS:

Our findings suggest that circulating miR-122 has potential as a novel, predictive, and reliable blood marker for viral-, alcohol-, and chemical-induced liver injury.

  S. Sun , R. Puttha , S. Ghezaiel , M. Skae , C. Cooper and R. Amin
  Objective: To determine the effect of coeliac disease and treatment with a gluten-free diet on growth and glycaemic control in asymptomatic children with Type 1 diabetes.
Methods: Data were compared in children with coeliac disease diagnosed by annual antibody screening and jejunal biopsy and treated with a gluten-free diet (n = 49) against individuals who were antibody negative (n = 49) matched for age, sex and duration of diabetes.
Results: No differences in growth were observed. In the years prior to diagnosis of coeliac disease, mean glycated haemoglobin (HbA1c) was lower in cases compared with control subjects [8.3 ± 1.1% vs. 8.7 ± 0.9%, P = 0.02 (mean ± sd)]. In cases, HbA1c deteriorated 12 months from the start of a gluten-free diet to levels similar to control subjects (8.9 ± 1.5% vs. 8.8 ± 1.5%, P-value for analysis of variance = 0.9). In regression analysis, the diagnosis of coeliac disease and start of a gluten-free diet was associated with a rise in HbA1c in the first year of treatment [odds ratio 1.56 (95% confidence intervals 1.16–2.10), P = 0.003] after adjusting for insulin dose and regimen and other variables.
Conclusions: In children with Type 1 diabetes, lower HbA1c prior to diagnosis of silent coeliac disease rises following treatment with a gluten-free diet to levels similar to those without coeliac disease. Although unproven, these observations may relate to abnormalities at the small bowel mucosa before the appearance of circulating coeliac antibodies.
  F. Zhang , L. Dong , C. P. Zhang , B. Li , J. Wen , W. Gao , S. Sun , F. Lv , H. Tian , J. Tuomilehto , L. Qi , C. L. Zhang , Z. Yu , X. Yang and G. Hu
  Aims  To investigate the trend in the prevalence of gestational diabetes mellitus during 1999-2008 in women living in urban Tianjin, China.

Methods  A universal screening for gestational diabetes mellitus has become an integral part of the antenatal care in Tianjin, China from 1998. A total of 105 473 pregnant women living in the six urban districts of Tianjin, China, participated in the gestational diabetes mellitus screening programme between December 1998 and December 2008. The screening test consisted of a 50-g 1-h glucose test. Women who had a glucose reading ≥ 7.8 mmol/l at the initial screening were invited to undergo the standard 2-h oral glucose tolerance test with a 75-g glucose load. Gestational diabetes mellitus was confirmed using the World Health Organization's diagnostic criteria.

Results  The adjusted prevalence of gestational diabetes mellitus increased by 2.8 times during 1999-2008, from 2.4 to 6.8% (P < 0.0001 for linear trend). In 2008, the age-specific prevalence of gestational diabetes mellitus was the highest among women aged 30-34 years (11.3%) and lowest among women aged 25 and under (1.2%). In women aged 35 years and more, the prevalence was 5.3%.

Conclusions  The prevalence of gestational diabetes mellitus has markedly been increasing in a universally screened urban Chinese female population and has become an important public health problem in China.

  S. Sun , J. Brown , J. Firman , A. Kamyab and E. McGill
  The objective of these studies was to determine the digestible threonine requirement for maintenance in turkeys during the starter period. Amino acid requirement data can be determined in multiple fashions. One method for determining amino acid requirements is through modeling. A portion of the data required for a comprehensive model is the maintenance requirement. Two studies were conducted to determine the maintenance requirement for threonine during the starter period for turkeys. Day-old poults (192 birds) were randomly assigned to pens to provide for six replications of eight treatments in each trial and a low protein diet was formulated so that different levels of threonine could be fed to young turkeys. The maintenance requirements of threonine were 25.94 and 29.51 mg/bird/day in experiment 1 and experiment 2, respectively. This information, coupled with the amino acid requirements for growth, will allow for the construction of an effective model to predict amino acid requirements over a wide range of environment and physiological conditions.
  S. Sun , J. Brown , J. Firman , A. Kamyab and E. McGill
  The objective of these studies was to predict the valine requirement for maintenance in starting turkeys for use in a future modeling system. Amino acid requirement data can be determined in multiple fashions. One method for determining amino acid requirements is through modeling. A portion of the data required for a comprehensive model is the maintenance requirement. Two studies were conducted to determine the maintenance requirement for valine during the starter period for turkeys. Day-old poults (192 birds) were randomly assigned to pens to provide for six replications of eight treatments in two trials and a low protein diet was formulated so that different levels of valine could be fed to young turkeys. The maintenance requirements of valine were approximately 31 and 43 mg/bird/day in experiment 1 and experiment 2, respectively. This information, coupled with the amino acid requirements for growth, will allow for the construction of an effective model to predict amino acid requirements over a wide range of environmental and physiological conditions.
 
 
 
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