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Articles by S. Sivabalan
Total Records ( 2 ) for S. Sivabalan
  S. Sivabalan and Venugopal P. Menon
  The aim of the study is to know the effect of high-fat and sucrose in the development of type 2 diabetes in Wistar rats. Several factors including high caloric diets, chronic positive caloric balance and the sedentary lifestyles are proposed as the causative factors in the development of type 2 diabetes but the exact mechanism involved is not known. Numerous studies on genetic models of obesity and diabetes induced by chemical destruction of pancreas are available, but the metabolic syndrome and diabetes observed in general population is mostly different from the genetic models and chemically induced diabetes. In this study we analyzed the effect of feeding, high-fat with or without sucrose, orally for 12 weeks. The rats were divided into three groups of twelve animals each. The groups are control, high-fat and high-fat with sucrose. After 12 weeks of treatment, fasting glucose, fasting plasma insulin, glucose tolerance test, plasma triglycerides, cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol were analyzed. Insulin resistance was analyzed by euglycemic clamp technique. Both high-fat diet and high-fat diet with sucrose impaired the lipid profile, glucose tolerance and have caused severe insulin resistance in the normal Wistar rats.
  S. Sivabalan and C.V. Anuradha
  Type 2 diabetes has emerged as an epidemic affecting millions of people all over the world. Several research findings suggest that oxidative stress is the triggering factor for the development of type 2 diabetes. Hyperglycemia and oxidative stress go hand in hand to accelerate the disease progression in a vicious cycle. In India, the medicinal herb Curcuma longa is used as a culinary food additive and also as a therapeutic agent for diabetes. Recent research evidenced that the curcuminoids present in Curcuma longa have several medicinal properties including anti-diabetic property. However, the bioavailability of curcumin is very less compared to its derivatives and its synthetic analogs. The synthetic analog of bisdemethoxycurcumin is reported to have increased bioavailability and stability but its effect on controlling oxidative stress, glucose absorption and gluconeogenesis have not yet been explored. The aim of this study was to evaluate the anti-oxidant and glucose lowering effects of bisdemethoxycurcumin analog (BDMCA) in comparison with curcumin. Anti-oxidant activity of BDMCA and curcumin was evaluated by measuring the rate of inhibition of iron-ascorbate induced lipid peroxidation in liver homogenate in vitro. Effect of these drugs on intestinal glucose absorption in Wistar rats and on gluconeogenesis in liver homogenate in vitro was evaluated to know their glucose lowering effects. We found that both the BDMCA and curcumin lower the gluconeogenesis in the hepatocytes and function as antioxidants in vitro in a similar manner. Both BDMCA and curcumin delays the intestinal glucose absorption but BDMCA delays the intestinal glucose absorption more effectively compared to curcumin.
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