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Articles by S. Shukla
Total Records ( 5 ) for S. Shukla
  H. Das , S.U. Ahmed , S.K. Shukla , S. Shukla , A. Latif and D. Sharma
  Mastitis represents a failure of innate immune mechanism of udder teat canal epithelial cells and peripheral PMN cells, whose cationic peptides constituted innate immunity. An attempt was made to examine in the year 2007, the actual presence of β-defensins peptides in milk of mastitis-affected buffalo (Bubalus bubalis), due to lack of such information. AU-PAGE revealed higher frequency and density of the peptides in case of mastitis milk as compared to normal milk sample, particularly in the most cationic zone with highest electrophoretic mobility or lower molecular weight region. These low molecular peptides were also separated out using 10 kDa cut-off membrane ultra filtration, which was subsequently examined for in vitro antibacterial sensitivity and subjected to SDS-PAGE and low molecular weight zone was further subjected to MALDI-TOF mass spectrometry, which identified the most anodic two peptides of about 5 kDa as β-defensin viz. The LAP (lingual antibiotic peptide) and BNBD-2 (bovine neutrophil beta-defensin-2) based on amino acid sequences unlike that of healthy buffalo milk. Sequence homology studies also supported mass spectrometry data as both the peptides shared 100 and 98.5% identities with cattle β-defensins, respectively. Antibacterial assay against S. aureus and E. coli revealed significant activity of these peptides against both gram-positive and gram-negative organisms at 10 μg concentration. It is concluded that expression of β-defensin peptides in ductal epithelium were induced in mastitis and these defensin peptides were also released into the milk.
  S. Dutta , P.K. Mishra , G.M. Prasad , S. Shukla and S.K. Chaulya
  Next generation internet protocol IPv6 provides great solution to the problems associated with IPv4. Large address space of IPv6 solves the problem of lack of IP addresses which was a major concern with the enormous growth of the internet. The new version of protocol provides innumerable benefits like auto-configuration, simple header, multicasting, quality of service, etc. which improve the overall functionality of IPv6. In the present study, the benefits of IPv6 on IPv4 have been discussed in detail including the lacuna of IPv6 in present day scenario. The future challenges have also been identified during the implementation of IPv6.
  S. Shukla and R.V. Shukla
  The study deals with the survey of the pollen grains at Korba an industrial town of Chhattisgarh. The study aimed to understand the pollen spectrum present in air, which is further helpful in study of allergic diseases. The study was carried out from March 2007 to February 2008. During the study air samples were taken by Rotorod air sampler using Vaseline coated slide. After sampling slides were mounted with glycerin-jelly and scanned under microscope. A total of 40 indigenous and exotic pollen type were obtained in which indigenous dominating ground flora are Cynodon dactylon (9.42 %) and Ocimum sanctum (7.13%) while exotic species along with exotic plants Parthenium hysterophorus (8.43), Cassia siamea (4.98), were obtained contributing maximum percentage of total pollen catch. Presently, alternation of primary vegetation in to industrial townships and planting exotic tree species has been considered to understand the biological relationship with human environment. Some pollen as Ageratum, Ailanthus, Amaranthus, Carica, Parthenium, Eucalyptus and many are allergic. During the study November 2007 is the month of highest occurrence where as, June 2007 and February 2008 is the month of lowest occurrence. In Korba city, the bio-particles particularly pollen grains which vary for their types, numbers, in different seasons has not been studied, therefore present study has been conducted for effective control of atmospheric particulate pollution.
  V. Gupta , S.K. Shukla , S.M. Shrivastava , S. Shukla , K. Kumar , D.P. Saxena , B. Shrivastava and M. Chaudhary
  The aim of this research was to study the influence of formulation parameters in the preparation of sustained release aceclofenac loaded PLGA microspheres by emulsion solvent diffusion technique. The methods used in this components and their concentration necessary for organogels formation were evaluated using phase diagram Solubility of aceclofenac was determined, Characterization of Poly (DL-lactide)-co-glycolide (PLGA) polymer, solubility assessment of aceclofenac, drug-excipients compatibility studies, in vitro analytical method development , preparation of aceclofenac-loaded PLGA microspheres, characterization of the formulations. Prepared microspheres were optimized and evaluated for different parameters and best formulation was subjected to in vitro drug release studies. The prepared microspheres were white, free-flowing and almost spherical in shape. In vitro drug release studies were carried out up to 24 h in three different pH media, i.e., 0.1 N HCl (pH 1.2), phosphate buffer (pH 6.8) and phosphate buffer (pH 7.4). The drug-polymer concentration of dispersed phase influences the particle size and drug release properties. In nut shell it may be concluded that sustained release aceclofenac microspheres can be successfully prepared and used parenterally with increased therapeutic value and reduced side effects.
  D.P. Saxena , S.K. Shukla , K. Kumar , R. Saxena , S. Saxena , S. Shukla , V. Gupta , R. Stephen , H. Kumar and L. Kumar
  The aim of this study was to test the in vitro antiplasmodial effect of extract and different fractions of Diospyros melanoxylan. Diospyros melanoxylon (Barks) are collected from the lower forest of Uttaranchal, which is identified by the local people. Plant materials are known as source of new antimicrobial agents, as a result search has been to discover new antibacterial drugs of plant origin. Six of eight methanolic extracts were found to have significant activity, in vitro anti-plasmodial effect of the water and ethanol extract of IC50 value is ranging from (IC50 = 116±9.19 and IC50 145±140 μg mL-1) and (IC50 = 35±0.0 and IC50 47±4.24 μg mL-1) of D. melanoxylon against chloroquine resistant and susceptible variety of Plasmodium falciparum. Least phytochemicals was observed in case of petroleum ether. These results, so obtained demonstrate the broad spectrum activity of D. melanoxylon bark extracts which may be useful in treatment of various microbial infections. Extracts of three of the four species of Indian Diospyros tested in this study showed antiplasmodial activities, with the best activity shown by D. melanoxylon. This species especially is worthy of further investigation to determine which of its constituents are responsible for the activity.
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