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Articles by S. Saxena
Total Records ( 3 ) for S. Saxena
  C. Millett , K. Khunti , J. Gray , S. Saxena , G. Netuveli and A. Majeed

AimTo examine associations between obesity, ethnicity and intermediate clinical outcomes in diabetes.

MethodsPopulation-based, cross-sectional study using electronic primary care medical records of 7300 people with diabetes from White, Black and south Asian ethnic groups.

ResultsThe pattern of obesity differed within ethnic groups, with rates significantly higher in younger when compared to older Black (women, 63% vs. 44%, P=0.002; men, 37% vs. 20%, P=0.005) and south Asian (women, 47% vs. 27%,P=0.01; men, 21% vs. 13%, P=0.05) people. Obese people with diabetes were significantly less likely to achieve an established target for blood pressure control (adjusted odds ratio 0.50, 95% confidence interval 0.42, 0.59). Differences in mean systolic blood pressure in obese and normal weight persons were significant in the White group but not in the Black groups or south Asian groups (6.9 mmHg, 1.9 mmHg and 2.7 mmHg, respectively). Differences in mean diastolic blood pressure between obese and normal weight persons were 4.8 mmHg, 3.6 mmHg and 3.4 mmHg in the White, Black and south Asian groups. Mean HbA1c and achievement of an established treatment target did not differ significantly with obesity in any ethnic group.

ConclusionsObesity is more prevalent amongst younger people than older people with diabetes in ethnic minority groups. The relationship between obesity and blood pressure control in diabetes differs markedly across ethnic groups. Major efforts must be implemented, especially in young people, to reduce levels of obesity in diabetes and improve long-term outcomes.

  S.K. Prasad , Taj N. Qureshi , S. Saxena , S. Qureshi , M. Mehar and S.K. Thakur
  It is obvious from several studies that the different neurotransmitters are associated with various metabolic activities of the body directly or indirectly via their effects on hypothalamic/pituitary hormone but regarding the control of reproductive system catecholamines seem to have a central role. In view of above fact the present study was designed to test whether neurotransmitter precursor L-Dihydroxyphenylalanine (i.e. L-DOPA, a dopamine precursor) feeding, can influence body growth and reproductive conditions in high food value poultry bird Japanese quail, Coturnix coturnix japonica. Experiments were performed in both male and female Japanese quail. Sexually immature (one week old) quail chicks were divided into two groups of 24 birds each. Group-I provided with normal diet and served as control while Group-II (experimental group) provided with food mixed with L-DOPA (50 mg/15 gm food). At the age of 3 weeks (when birds were sexually distinguished) Group-I was divided into two sub groups IA (male) and IIA (female) of six birds each. Similarly Group II was sub divided into IB (male) and IIB (female) of 6 birds each. Observations were made up to the age of 5 weeks. Male experimental group (IB) showed significantly increased testicular activity, cloacal gland volume, body weight, plasma testosterone and LH level in comparison to control (IA). Similarly female experimental group (IIB) showed significantly high weight of reproductive organs (uterus, ovary, oviduct, ovarian follicle), body weight, egg weight and size and number of follicles. On the other hand plasma prolactin level was significantly low in comparison to control (IIA). Results suggest that the development and reproduction in Japanese quail might be associated with dopaminergic system of the brain.
  D.P. Saxena , S.K. Shukla , K. Kumar , R. Saxena , S. Saxena , S. Shukla , V. Gupta , R. Stephen , H. Kumar and L. Kumar
  The aim of this study was to test the in vitro antiplasmodial effect of extract and different fractions of Diospyros melanoxylan. Diospyros melanoxylon (Barks) are collected from the lower forest of Uttaranchal, which is identified by the local people. Plant materials are known as source of new antimicrobial agents, as a result search has been to discover new antibacterial drugs of plant origin. Six of eight methanolic extracts were found to have significant activity, in vitro anti-plasmodial effect of the water and ethanol extract of IC50 value is ranging from (IC50 = 116±9.19 and IC50 145±140 μg mL-1) and (IC50 = 35±0.0 and IC50 47±4.24 μg mL-1) of D. melanoxylon against chloroquine resistant and susceptible variety of Plasmodium falciparum. Least phytochemicals was observed in case of petroleum ether. These results, so obtained demonstrate the broad spectrum activity of D. melanoxylon bark extracts which may be useful in treatment of various microbial infections. Extracts of three of the four species of Indian Diospyros tested in this study showed antiplasmodial activities, with the best activity shown by D. melanoxylon. This species especially is worthy of further investigation to determine which of its constituents are responsible for the activity.
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