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Articles by S. Salehi
Total Records ( 2 ) for S. Salehi
  M. Shariati , K. Parivar , S.H. Oryan , A. Shakravi , R. Alizadeh and S. Salehi
  In this research, the effect of 2, 6-diaminopyridinum as a new phenanthroline derivative was studied on the hypophysis-gonad axis, testicular tissue and sperm production in male Balb/C mice. Fifty adult male Balb/C mice were divided in five groups. First group was considered as untreated control. Saline was injected to second group and the remaining three groups received intraperitoneal injection of 15, 20 and 25 mg kg-1 of 2, 6- diaminopyridinum every other day for 20 days. The LD50 was determined to be 35 mg kg-1 body weight. The testicular tissues were studied morphologically and the serum concentration of FSH, LH and testosterone were measured. The results showed that 25 mg kg-1 diaminopyridinum decreased the number of germ cells significantly and serum testosterone level with no change on FSH and LH levels. This study indicates that 25 mg kg-1 of phenanthroline may directly affect testicular tissue causing a lower testosterone level and spermatogenesis in mice.
  Sh. Jalili , M. Ilkhanipour , R. Heydari , S. Salehi and A.A. Farshid
  Endosulfan, an organochlorine insecticide and acaricide, has been used in agriculture for several years. The aim of present study was to analyze the cardiotoxic effect of endosulfan which caused biochemical changes in heart of male rats and to evaluate the possible protective effect of vitamin E. Vitamin E (200mg/kg, twice a week), endosulfan (2mg/kg per day, once a day in corn oil) and Vitamin E (200mg/kg, twice a week) + endosulfan (2mg/kg per day, once a day in corn oil) combination were given to rats (n=6) orally via gavage for 4 weeks. GPx and CAT activities were measured in tissues samples. Gpx, CAT and SOD activities increased in the endosulfan - treated group heart tissues compared to control group (P<0.01, P<0.05 and P<0.01 respectively). GPx and SOD activities decreased in the endosulfan+vitamin E - treated group compared to endosulfan - treated group (P<0.05). Decrease of CAT activity was not significant in the endosulfan+vitamin E - treated group compared to endosulfan - treated group. We conclude that vitamin E significantly reduces endosulfan - induced oxidative stress in rat heart.
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