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Articles by S. Nisar
Total Records ( 2 ) for S. Nisar
  M. A. Ganie , B. A. Laway , S. Nisar , M. M. Wani , M. L. Khurana , F. Ahmad , S. Ahmed , P. Gupta , I. Ali , I. Shabir , A. Shadan , A. Ahmed and S. Tufail
  Aims  Wolfram syndrome, also known as DIDMOAD, is a relatively rare inherited neurodegenerative disorder, first evident in childhood as an association of juvenile-onset diabetes mellitus and optic atrophy, followed by diabetes insipidus and deafness. The aim of the study was to examine the clinical profile of patients with DIDMOAD syndrome presenting to a tertiary care hospital in north India.

Methods  Clinical presentation of juvenile-onset diabetes mellitus fulfilling the diagnosis of Wolfram syndrome was studied using a prepared standardized form.

Results  Subjects with juvenile-onset non-autoimmune diabetes mellitus attending the diabetic clinic at a tertiary care centre in north India were followed for 10 years and a diagnosis of fully developed Wolfram syndrome was confirmed in seven individuals. The series consisted of five male and two female patients with a mean age of 17.5 ± 7.34 years. Two subjects had consanguinity and none had any other family member affected. Optic atrophy was present in all, sensorineural hearing loss in 4/7, central diabetes insipidus in 4/7 and nephrogenic diabetes insipidus in 2/7 subjects. The new associations found were: spastic myoclonus, short stature with pancreatic malabsorption, nephrogenic diabetes insipidus, cyanotic heart disease and choledocholithiasis with cholangitis. Genetic analysis revealed mutation in exon 8 of the WFS1 gene in all the cases studied.

Conclusions  The present clinical series of Wolfram syndrome reveals a varied clinical presentation of the syndrome and some new associations.

  M. Ashraf and S. Nisar
  Seeds of Salvadora oleiodes (locally called Jhal or Pelun) were tested for their germination performance and membrane leakage properties during early hours of imbibtion. The optimal germination temperature determined was 30°C wherein 85 percent germination was obtained within 5 days of imbibition. When seeds with testa (intact) or without testa (‘naked’) were immersed in water and electrical conductance (E.C.) measured, higher E.C. values were obtained in ‘naked’ seeds than the intact ones. Potassium ions in leachates of 1 h imbibed seeds were 14-18 ppm/seed in intact and 133 ppm/seed in ‘naked’ seeds. Inorganic phosphorus contents (Pi) were 61 ppm/‘naked’ seed which remained un-detectable in leachates of intact ones. Less tham 1 ppm/seed Na was detected in leachates of ‘naked’ seeds. Amino acids and carbohydrate contents (33 μmol/seed and 68 μg/seed, respectively) were among organic solutes effluxed during early minutes of imbibition.
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