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Articles by S. Luzio
Total Records ( 2 ) for S. Luzio
  R. M. Bracken , D. J. West , J. W. Stephens , L. P. Kilduff , S. Luzio and S. C. Bain
  Aim This study examined the effects of reductions to pre-exercise rapid-acting insulin dose on changes in blood beta-hydroxybutyrate, glucose, acid-base balance and counter-regulatory hormone responses to prolonged running in individuals with Type 1 diabetes. Methods Following ethical approval, seven participants with Type 1 diabetes (34 ± 2 years, BMI 27 ± 1 kg/m2) completed this study. After preliminary testing, participants attended the laboratory four times, each time consuming a 1.12MJ meal (60 g carbohydrate, 2 g fat, 2 g protein), with randomized amounts of their rapid-acting insulin: Full dose (mean 7.3 ± 0.2 units), 75% dose (mean 5.4 ± 0.1 units), 50% dose (mean 3.7 ± 0.1 units) or 25% dose (mean 1.8 ± 0.1 units). After 2-h rest, participants completed 45 min running at 70 ± 1% peak rate of oxygen consumption (VO2peak). Blood metabolites and hormones were recorded over the 2-h rest and 3-h recovery. Data were analysed using repeated-measures ANOVA. Results Serum insulin peaked at 60 min in all conditions and was lowest after 25% insulin dose compared with full dose (P = 0.03). After the 25% insulin dose immediately pre-exercise glucose concentration was higher than after the full or 50% dose (< 0.05). Resting beta-hydroxybutyrate gradually decreased during 2-h rest (P < 0.05) with a similar post-exercise peak of beta-hydroxybutyrate at 3 h (P > 0.05). Post-exercise blood pH increased for 5 min to a similar extent with all insulin doses , but the rise with the 25% dose was less compared with the full dose (P = 0.01). Blood lactate and plasma catecholamines increased after running similarly with all insulin reduction conditions (P < 0.05). Blood glucose area under the curve (BGauc) after the 25% insulin dose was greater than after the 75% dose (P = 0.02). Conclusion Ketogenesis following running was not influenced by reductions in pre-exercise rapid-acting insulin dose. This important preparatory strategy aids preservation of blood glucose but poses no greater risk to exercise-induced ketone body formation.
  D. Turner , S. Luzio , L. P. Kilduff , B. J. Gray , G. Dunseath , S. C. Bain , M. D. Campbell , D. J. West and R. M. Bracken
 

Aims

To determine the influence of different volumes of resistance exercise on circulating interleukin-6 (IL-6) and to explore the relationships between IL-6 and glycaemia.

Methods

Eight participants with complication-free Type 1 diabetes, whose mean ± sem age was 38 (6) years, mean ± sem HbA1c concentration was 71 ±11 mmol/mol (8.7 ±1.0%) and mean ± sem Type 1 diabetes duration was 15 ±13 years, attended the research facility after an overnight fast on four separate occasions, having administered their basal insulin the night before (glargine 27.5±3.1U, n=8), but omitted morning rapid-acting insulin. Participants completed either a one-set (14-min), two-set (28-min), or three-set (42-min) resistance exercise trial (eight exercises x 10 repetitions) at 67±3% one-repetition maximum followed by a 60-min recovery, or a resting control trial. Venous blood samples were taken before and after exercise. Data were analysed using repeated-measures anova (P≤0.05).

Results

Whereas IL-6 levels remained similar to baseline levels after one set of resistance exercises (30 min, P=0.287; 60 min, P=0.318), IL-6 levels were > baseline levels at 60 min post-exercise after a two-set exercise trial (2.94 ± 0.94 pg/ml, P=0.002) and doubled at both 30 min (4.01 ± 1.00 pg/ml, P=0.048) and 60 min (4.28 ± 1.25 pg/ml, P=0.084) post-exercise after the three-set resistance exercise trial. Post-exercise blood glucose area under the curve (mmol/l/60 min) was greater after both the one-set (P=0.025) and two-set trials (P=0.008), than after the control trial, but similar between the three-set trial and the control trial (P=0.240). The rise in IL-6 from baseline to peak concentration significantly correlated inversely with blood glucose area under the curve (r=-0.65, P=0.041).

Conclusions

Circulating IL-6 is increased by resistance exercise in a volume-dependent manner, and resistance exercise-induced increases in IL-6 correlated with reductions in post-exercise hyperglycaemia in Type 1 diabetes, suggesting a role for IL-6 in improving post-resistance exercise glycaemic disturbances in Type 1 diabetes.

 
 
 
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