Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
Articles by S. Luzio
Total Records ( 2 ) for S. Luzio
  R. M. Bracken , D. J. West , J. W. Stephens , L. P. Kilduff , S. Luzio and S. C. Bain
  Aim This study examined the effects of reductions to pre-exercise rapid-acting insulin dose on changes in blood beta-hydroxybutyrate, glucose, acid-base balance and counter-regulatory hormone responses to prolonged running in individuals with Type 1 diabetes. Methods Following ethical approval, seven participants with Type 1 diabetes (34 ± 2 years, BMI 27 ± 1 kg/m2) completed this study. After preliminary testing, participants attended the laboratory four times, each time consuming a 1.12MJ meal (60 g carbohydrate, 2 g fat, 2 g protein), with randomized amounts of their rapid-acting insulin: Full dose (mean 7.3 ± 0.2 units), 75% dose (mean 5.4 ± 0.1 units), 50% dose (mean 3.7 ± 0.1 units) or 25% dose (mean 1.8 ± 0.1 units). After 2-h rest, participants completed 45 min running at 70 ± 1% peak rate of oxygen consumption (VO2peak). Blood metabolites and hormones were recorded over the 2-h rest and 3-h recovery. Data were analysed using repeated-measures ANOVA. Results Serum insulin peaked at 60 min in all conditions and was lowest after 25% insulin dose compared with full dose (P = 0.03). After the 25% insulin dose immediately pre-exercise glucose concentration was higher than after the full or 50% dose (< 0.05). Resting beta-hydroxybutyrate gradually decreased during 2-h rest (P < 0.05) with a similar post-exercise peak of beta-hydroxybutyrate at 3 h (P > 0.05). Post-exercise blood pH increased for 5 min to a similar extent with all insulin doses , but the rise with the 25% dose was less compared with the full dose (P = 0.01). Blood lactate and plasma catecholamines increased after running similarly with all insulin reduction conditions (P < 0.05). Blood glucose area under the curve (BGauc) after the 25% insulin dose was greater than after the 75% dose (P = 0.02). Conclusion Ketogenesis following running was not influenced by reductions in pre-exercise rapid-acting insulin dose. This important preparatory strategy aids preservation of blood glucose but poses no greater risk to exercise-induced ketone body formation.
  D. Turner , S. Luzio , L. P. Kilduff , B. J. Gray , G. Dunseath , S. C. Bain , M. D. Campbell , D. J. West and R. M. Bracken


To determine the influence of different volumes of resistance exercise on circulating interleukin-6 (IL-6) and to explore the relationships between IL-6 and glycaemia.


Eight participants with complication-free Type 1 diabetes, whose mean ± sem age was 38 (6) years, mean ± sem HbA1c concentration was 71 ±11 mmol/mol (8.7 ±1.0%) and mean ± sem Type 1 diabetes duration was 15 ±13 years, attended the research facility after an overnight fast on four separate occasions, having administered their basal insulin the night before (glargine 27.5±3.1U, n=8), but omitted morning rapid-acting insulin. Participants completed either a one-set (14-min), two-set (28-min), or three-set (42-min) resistance exercise trial (eight exercises x 10 repetitions) at 67±3% one-repetition maximum followed by a 60-min recovery, or a resting control trial. Venous blood samples were taken before and after exercise. Data were analysed using repeated-measures anova (P≤0.05).


Whereas IL-6 levels remained similar to baseline levels after one set of resistance exercises (30 min, P=0.287; 60 min, P=0.318), IL-6 levels were > baseline levels at 60 min post-exercise after a two-set exercise trial (2.94 ± 0.94 pg/ml, P=0.002) and doubled at both 30 min (4.01 ± 1.00 pg/ml, P=0.048) and 60 min (4.28 ± 1.25 pg/ml, P=0.084) post-exercise after the three-set resistance exercise trial. Post-exercise blood glucose area under the curve (mmol/l/60 min) was greater after both the one-set (P=0.025) and two-set trials (P=0.008), than after the control trial, but similar between the three-set trial and the control trial (P=0.240). The rise in IL-6 from baseline to peak concentration significantly correlated inversely with blood glucose area under the curve (r=-0.65, P=0.041).


Circulating IL-6 is increased by resistance exercise in a volume-dependent manner, and resistance exercise-induced increases in IL-6 correlated with reductions in post-exercise hyperglycaemia in Type 1 diabetes, suggesting a role for IL-6 in improving post-resistance exercise glycaemic disturbances in Type 1 diabetes.

Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility