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Articles by S. Kavimani
Total Records ( 5 ) for S. Kavimani
  V.M. Mounnissamy , S. Kavimani , V. Balu and S. Darlin Quine
  The ethanol, water and chloroform extracts of the aerial parts of Cansjera rheedii J. Gmelin (Opiliaceae) were investigated for activity against Indian earthworms Pheretima posthuma. Various concentrations (5-40 mg mL-1) of each extract were tested, which involved determination of time of paralysis and time of death of the worms. All three extracts exhibited considerable anthelminthic activity. All the extracts (i.e., aqueous, chloroform and ethanol) at the tested dose (5-40 mg mL-1) level produced significant activity (p < 0.001) when compared with piperazine citrate (15 mg mL-1) and albendazole (20 mg mL-1) which were included as standard reference and normal saline as control. The present study indicates the potential usefulness of Cansjera rheedii aerial parts as anthelminthic activity.
  N. Anitha , J.V. Rao , S. Kavimani and V. Himabindu
  The present study is aimed to explore the pharmacodynamic interaction of metformin with statins like atorvastatin and rosuvastatin in rats. Wistar albino rats of either sex (150-200 g) were induced diabetes by administering alloxan and they were divided into six groups, each consisting of six rats. Normal control group (1) is treated with 1%w/v carboxy methyl cellulose (CMC) suspension. Group 2 served as diabetic control. To the diabetic 3rd, 4th and 5th group metformin, atorvastatin and rosuvastatin were administered orally respectively for 7 days. The combination of metformin + atorvastatin and metformin + rosuvastatin were administered to the 6th and 7th group of diabetic rats for 7 days. On the last day blood samples were collected, serum was isolated and subjected to glucose, triglycerides (TG), total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL) estimation. Body weight was also calculated. Metformin significantly reduced the serum glucose level in diabetic rats. Atorvastatin and rosuvastatin produced mild hypoglycemia. On the other hand the combination of metformin + atorvastatin and metformin + rosuvastatin significantly reduced the serum glucose level when compared to metformin alone. Atorvastatin and rosuvastatin significantly reduced the serum TG, TC and LDL and increased HDL level. Metformin also altered the lipid profile of diabetic rats. Whereas the combination of metformin + atorvastatin and metformin + rosuvastatin significantly reduced the lipid profile when compared to atorvastatin and rosuvastatin alone. The combination of drugs also increased the body weight of diabetic animals. The antidiabetic drug metformin enhanced the hypolipidemic activity of atorvastatin and rosuvastatin. Similarly atorvastatin and rosuvastatin enhanced the hypoglycemic activity of metformin due to pharmacodynamic interactions.
  V.M. Mounnissamy , S. Kavimani , V. Balu and S. Darlin Quine
  The antipyretic activity of ethanol (95%) extracts of Cansjera rheedii J. Gmelin aerial parts of the plant was evaluated against brewer`s yeast-induced pyrexia in rats to assess their antipyretic activity. Rectal temperatures were recorded before and after inducing pyrexia at interval of one hour to five hours. At the same time parallel experiments were run with a standard antipyretic paracetamol (100 mg kg-1) and control (Normal Saline 5 mL kg-1). Ethanol extract of Cansjera rheedii J. Gmelin at dose of 250 mg and 500 mg kg-1 body weight showed the antipyretic activity significantly (p<0.001) compared to that of control.
  N. Subhashini , G. Nagarajan and S. Kavimani
  Trigonella foenum graecum (Leguminosae) (Eng: fenugreek, Tamil: Vendayam) is a well known spicy agent and seeds are used traditionally for several medicinal purposes. In present study the ethanol extract of seeds from Trigonella foenum graecum (EETFG) was evaluated for its anti- inflammatory activity in acute (carrageenan, histamine and serotonin induced rat paw oedema) and chronic models (cotton pellet induced granuloma). In all models the EETFG (75 and 150 mg kg-1 b.wt. p.o.) exhibited significant anti-inflammatory activity (p<0.001) in a dose dependent manner when compared with saline control. Indomethacin (10 mg kg-1 b.wt. p.o.) was used as reference drug. The EETFG was evaluated for its antioxidant properties by 1, 1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging assay and in vitro lipid peroxidation induced by the Fe2+-ascorbate system in rat liver homogenate. In DPPH radical scavenging assay, the EETFG demonstrated marked and dose dependent free radical scavenging effect and the mean inhibitory concentration (IC50) of the EETFG was found to be 75.2 μg mL-1 while the ascorbic acid (reference) exhibited 43.7 μg mL-1. The EETFG effectively inhibited the lipid peroxidation in a dose related manner showing the IC50 value of 279.1 μg mL-1, whereas the quercetin (reference) showed 46.6 μg mL-1. These findings revealed that the Trigonella foenum graecum seeds had remarkable acute and chronic anti-inflammatory and in vitro antioxidant actions in the tested models validating its traditional uses.
  B. Rajkapoor , S. Kavimani , V. Ravichandiran , K. Sekhar , R. Senthil Kumar , M. Rupesh Kumar , M. Pradeepkumar , John Wilking Einstein and E.P. Kumar
  The effect of ethanol extract of stems of Indigofera aspalathoides Vahl (Papilionaceae) (EIA) was evaluated for anti-arthritic activity on complete Freund’s adjuvant-induced (CFA-induced) arthritis in rats. The EIA was administered orally at doses of 250 and 500mg/kg daily for 30 days. The paw volume was measured on days 7, 14, 21 and 30. At the end of day 30, the rats were sacrificed and various biochemical parameters such as serum aspartate transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total cholesterol and triglycerides were estimated. Antioxidant enzymes, such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx) and lipid peroxide (LPO) in the liver and kidney of normal, arthritic control and EIA treated rats were studied. Oral administration of EIA effectively inhibits rat paw edema in a dose-dependent manner. EIA significantly (P<0.01) altered the biochemical parameters which were affected in arthritic rats. There was significant alteration in LPO, SOD, catalase, and GPx levels when compared to arthritic control rats. Our findings showed a significant anti-arthritic effect of EIA against CFA-induced arthritis in rats.
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