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Articles by S. Kabir
Total Records ( 2 ) for S. Kabir
  K.D. Alam , M.K. Hosain , S. Kabir , R.M.A.A. Chowdhury , S. Mahjabeen , M.S. Mondal , S.M. Abuzar and M.F. Rahman
  Combination therapy is now very common for the effective management of cardiovascular problems. The aim of the present study was to evaluate how clinically two important drugs, Amlodipine Besylate and Atorvastatin Calcium, bind with serum protein and the effect of drug-protein binding when they administered concomitantly. In this study the binding chemistry of Amlodipine and Atorvastatin to Bovine Serum Albumin (BSA) was evaluated by Equilibrium dialysis method utilizing Warfarin Sodium (site-I specific probe) and Diazepam (site-II specific probe). Association constant and number of binding sites of the experimental drugs were carried out at pH values of 6.4 and 7.4. The non-liner curve of the plot suggests the presence of at least two classes of binding site (low affinity binding site and high affinity binding site) of experimental drugs to BSA. In both cases of high affinity binding site and low affinity binding, value of association constants of experimental drugs were found higher at pH 7.4. Both of the experimental drugs found to bind site-I preferentially as both of drugs displaced Warfarin Sodium more from the binding site on BSA than that of Diazepam. During concurrent administration of Amlodipine Besylate and Atorvastatin Calcium in presence or absence of diazepam, it was found that the ability of Atorvastatin Calcium to displace Amlodipine Besylate is more than the ability of Amlodipine Besylate to displace Atorvastatin Calcium from the binding site on BSA. The ability of experimental drugs to displace each other is found more in presence of Diazepam. As both drugs compete for the same binding site care should be given during concurrent administration of these two drugs.
  M. Obayed Ullah , M. Jashim Uddin , K. Hamid , S. Kabir , M. Azizur Rahman and M.S.K. Choudhuri
  The study was carried out to investigate the safety profile as well as the effect of “Rohitakarista” (RHT) on various biochemical parameters of rats` plasma after chronic administration. RHT, a classical Ayurvedic preparation used in hepatosplenic disorders, was administered per oral route at a dose of 100 mg kg-1 body weight, once daily, up to 46 days for all the experiments. Forty albino rats (Rattus novergicus: Sprague-Dawley strains), equally of both sexes, were randomly grouped into four where each group had ten animal/sex. One male and one female group were used as control and other groups were used as test. In the male, rats there was a statistically insignificant increase (p = 0.763) in the total protein but there was a statistically significant increase (p = 0.022) in the total protein content of the plasma of female rats. Statistically very high significant increase (male: p = 0.001 and female: p = 0.001) in the albumin content of the plasma was noted in both sexes. In case of bilirubin, interestingly it was decreased very high significantly (p = 0.001) in plasma of male rats but increased very high significantly (p = 0.001) in the plasma of female rats. In the male rats, statistically there was a very high significant decrease (sGPT: p = 0.001, sGOT: p = 0.001 and ALP: p = 0.001) in the sGPT, sGOT and ALP activities in the plasma. On the other hand, statistically there was a very highly significant increase (sGPT: p = 0.001, sGOT: p = 0.001 and ALP: p = 0.001) in the sGPT, sGOT and ALP activities in the plasma of female rats. Very high significant decrease (male: p = 0.001 and female: p = 0.001) in creatinine in plasma of both sexes were observed after chronic administration of RHT. Urea in the plasma was decreased very high significantly (p = 0.001) in plasma of male rats but increased very high significantly (p = 0.001) in the plasma of female rats. There was high significant increase (p = 0.002) in uric acid in male rats. On the contrary, no significant increase (p = 0.324) of uric acid was observed in female rats.
 
 
 
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