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Articles by S. Jagannathan
Total Records ( 4 ) for S. Jagannathan
  K.C. Shivanandappa , S. Jagannathan , S. Lokesh , R. Vijayakumar and K.R. Mani
  Studies have been undertaken to investigate, the effect of impeller number and its position upon the growth yield of Bordetella pertussis strain 509 during large scale batch cultivation. It was shown that, the maximum growth yield opacity was found to be 70 IOU mL–1 at 48 h cultivation in single impeller fixed at the bottom position of fermentor vessel. Whereas the optimal and moderate culture opacity 60 and 50 IOU mL–1 was observed during the two impellers mounted at two different positions on the shaft. Similarly the least growth yield was obtained during three impeller located at top, middle and bottom region of the shaft and the final opacity was found to be 30 IOU mL–1 at the end of 48 h cultivation with an increasing of culture pH 8.02. However, in two impeller combination experimental study also showed moderate growth yield at 48 h could give to homogenized mixing and good aeration. Thus, the two different location of the impeller combination influences two vortex flows, enhances optimal growth rate, viz; the lower impeller act as gas disperser and creates radial velocity with higher rates of air dispersion, whereas the upper impeller pumps the broth towards down thus the combined agitation of the broth leads to good mixing and even transfer of Dissolved Oxygen (DO2) to the growing cells and found moderate bacterial growth. In the combination of three impellers mounted at three different positions experimental study shown that, lesser growth yield at the end of 48 h cultivation, due to higher forth accumulation.
  C. Kathirvel , M. Gopinath , K. Porkumaran and S. Jagannathan
  With the concern regarding the state of our deteriorating planet, environmentally friendly solutions are becoming more prominent. This study presents a new system configuration of the front-end rectifier stage consisting of CUK-SEPIC fused converter for a hybrid wind/photovoltaic energy system. The configuration allows the two sources to supply the load separately or simultaneously depending on the availability of the energy sources. With this converter integration, additional input filters are not necessary to filter out high frequency harmonics. The fused multi input rectifier stage also allows Maximum Power Point Tracking (MPPT) to be used to extract maximum power from the wind and sun when it is available. A microcontroller based control method is used for the Maximum Power Point Tracking (MPPT) of the energy system. For the reduction of tracking time, Fuzzy Logic Control algorithm is implemented with the embedded microcontroller for improved performance. Operational analysis of the proposed system will be discussed in this study. Simulation results are given to highlight the merits of the proposed circuit.
  S. Jagannathan , P. Rahul Gandhi and R. Vijayakumar
  Rabies is an acute disease of vertebrate animals which may affect all animals from amphibian to man and it is a single stranded negative sense RNA virus belonging to the genus Lyssavirus of the family Rhabdoviridae. The production of vaccines, diagnosis and further research will therefore continue in this field because a cure for rabies would be a big boon for the developing countries. Virus inactivation is essential for the preparation of vaccines, diagnostic reagent and research purposes. The beta propiolactone (βPL) is widely used as an inactivatent; βPL is very considerable value in the production of biological for virus inactivation and perhaps for DNA inactivation. The inactivation results indicate that the rate of inactivation is directly proportional to the concentration of βPL used. Assessment of the residual βPL present in the vaccine is a mandatory test to vaccine. Vaccine manufacturing also assess the efficacy of inactivation procedure by various in process quality control tests such as tissue culture virus amplification test and inactivation kinetics. This experiments are based on the changing the parameters as well as the various concentration of βPL in the clarified, concentrated high titer of PV11 rabies strain, subsequently that are further purified and formulated with suitable additives and stabilizers. The immunogenicity of the vaccines is analyzed. During the βPL inactivation kinetics gives an idea of the predictable time of inactivation and also the order of inactivation, validation of the inactivation process is an essential part of quality assurance. In the immunobiological industry the time is a crucial factor because to get more inactivated viral harvest yield in a short period and they are processed to further purification and downstream processing. This findings is to reduce the time frame and the residual βPL in various level influenced the tissue culture derived anti rabies vaccine.
  S. Jagannathan , S. Chaansha , K. Rajesh , T. Santhiya , C. Charles and K.N. Venkataramana
  Vero cells are utilized for production of rabies vaccine. This study deals with the optimize quantity media require for the rabies vaccine production in the smooth roller surface. The rabies virus (Pasteur vaccine strain) is infected to monolayer of the various experimented bottles. To analyze the optimal quantity of media for the production of rabies viral harvest during the process of Vero cell derived rabies vaccine. The trials are started from 200 to 400 mL (PTARV-1, PTARV-2, PTARV-3, PTARV-4 and PTARV-5). The samples are taken in an appropriate time intervals for analysis of In Process Quality Control (IPQC) tests. The collected viral harvests are further processed to rabies vaccine in a pilot level and in addition to scale up an industrial level. Based on the evaluation the PTARV-2 (250 mL) show highly encouraging results for the Vero cell derived rabies vaccine production.
 
 
 
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