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Articles by S. Huang
Total Records ( 2 ) for S. Huang
  W Chen , Y Luo , L Liu , H Zhou , B Xu , X Han , T Shen , Z Liu , Y Lu and S. Huang
 

Cryptotanshinone (CPT), a natural compound isolated from the plant Salvia miltiorrhiza Bunge, is a potential anticancer agent. However, little is known about its anticancer mechanism. Here, we show that CPT inhibited cancer cell proliferation by arresting cells in G1-G0 phase of the cell cycle. This is associated with the inhibition of cyclin D1 expression and retinoblastoma (Rb) protein phosphorylation. Furthermore, we found that CPT inhibited the signaling pathway of the mammalian target of rapamycin (mTOR), a central regulator of cell proliferation. This is evidenced by the findings that CPT inhibited type I insulin-like growth factor I– or 10% fetal bovine serum–stimulated phosphorylation of mTOR, p70 S6 kinase 1, and eukaryotic initiation factor 4E binding protein 1 in a concentration- and time-dependent manner. Expression of constitutively active mTOR conferred resistance to CPT inhibition of cyclin D1 expression and Rb phosphorylation, as well as cell growth. The results suggest that CPT is a novel antiproliferative agent. Cancer Prev Res; 3(8); 1015–25. ©2010 AACR.

  L. C Schmitt , M. V Paterno and S. Huang
 

Background: The International Knee Documentation Committee (IKDC) Subjective Knee Evaluation Form (IKDC Knee Form) is a valid, reliable, and responsive measure of knee-related symptoms, function, and sports activities in adults. Despite the incidence of knee injuries in younger individuals, the measurement characteristics of the IKDC Knee Form have not been established.

Hypothesis/Purpose: The purpose of this study was to investigate the validity and internal consistency of the IKDC Knee Form in pediatric, adolescent, and young adult patients with a variety of knee conditions. The authors hypothesized that the IKDC Knee Form would be a valid and consistent measure of knee function in these age groups.

Study Design: Cohort study (diagnosis); Level of evidence, 2.

Methods: The IKDC Knee Form and Pediatric Quality of Life Inventory 4.0 Generic Core Scales (PedsQL) physical functioning component were administered to 673 individuals between 6 and 18 years of age. The internal consistency and validity of the IKDC Knee Form were determined for the entire cohort and for age group cohorts (pediatric, 6-12 years; adolescent, 13-15 years; young adult, 16-18 years) using the PedsQL physical functioning component for comparison.

Results: The results were similar across all age groups. In the original format, internal consistency was high and factor analysis showed a single, dominant component underlying the item responses for each age group. Items 2, 3, and 6 may contribute to measurement error in young individuals. Correlation between the IKDC Knee Form and PedsQL physical functioning component score was moderately high for the entire cohort (r = .83) and for all age groups (pediatric, r = .84; adolescent, r = .84; young adult, r = .79).

Conclusion: In its current form, the IKDC Knee Form is a valid and consistent knee-specific measure of symptoms, function, and sports activity in individuals between the ages of 6 and 18 years with a variety of knee problems. Further work is needed to establish the reliability and responsiveness of the IKDC Knee Form for this age group.

 
 
 
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