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Articles by S. Ganabadi
Total Records ( 6 ) for S. Ganabadi
  S. Ganabadi , S. Mutuviren , M.A. Hilmi , S.M.A. Babjee , H. Yaakub and S. Fakurazi
  Carcass composition of three breed of chicken was compared: jungle fowl, broiler and Malaysian indigenous chicken. The chickens were sacrificed and were divided into forequarter and hindquarter. The forequarter was further divide into breast, wing and ribs. The muscle, bone, fat and skin of all different portions were separated, weighed and recorded. The results showed that broilers have significantly higher muscle weight compared to indigenous chicken and jungle fowl. The jungle fowl has significantly higher bone weight with least fat compared to the other two breeds The carcass composition of indigenous chicken is always in between the broiler and jungle fowl. Present results show that different habitat and feeding pattern of these chickens do contribute to these changes.
  S. Ganabadi , S. Mutuviren , M.A. Hilmi , S.M.A. Babjee , H. Yaakub and S. Fakurazi
  F.J. AL-Saffar , S. Ganabadi , H. Yaakub and S. Fakurazi
  The objective of this study was to apply and compare two different experimental osteoarthritis (OA) methods in the rat, namely: Collagenase induced OA (CO) and Monosodium iodoacetate induced OA (MIA) models. The assessment of OA development and progression were performed through three different periods (2, 4 and 6 weeks). Intra-articular injection of either 4 mg joint-1 CO type II or 3 mg joint-1 MIA, were administered to the adult male Sprague Dawley rats, into their right knee joints. Evaluation of OA changes in the knees was achieved with both histopathology score system and radiography approach. Gross results revealed earliest changes such as swelling and redness of the right knee joints of all rats injected with either CO or MIA. Joint dissection revealed distinct thickening of the joint capsule in MIA-injected rats than in CO group. Present finding revealed early development of radiographical as well as histopathological changes in MIA injected group. However, both OA injected groups resulted in a chronic joint degeneration, measured by cellular changes, matrix degradation, subchondral changes and marginal osteophyte formation. Present findings showed significantly higher histopathological score in MIA injected group than those of CO in each of the three selected periods for OA induction. In conclusion, present results demonstrated that MIA can induce OA changes in a shorter period of time than CO in the Sprague Dawley rat. Radiography approach could be a useful tool to evaluate osteoarthritic changes in the knee joints.
  F.J. Al-Saffar , S. Ganabadi and S. Fakuraz
  The main aim of this study was to evaluate oral administration of Channa striatus extract on monosodium iodoacetate induced knee osteoarthritis changes in rat. About 40 rats were randomly assigned to four groups. Rats in the 1st and 2nd groups were treated with the extract in a same dose but with two different courses of therapy. Rats in the 3rd group were treated with celecoxib as a positive control where as the 4th group was treated with normal saline as a negative control. Evaluation of osteoarthritis changes was assessed with the aid of radiology, histopathology score and immunohistochemistry to explore immunoreactivity in the synovium. Assay of prostaglandins in the serum had been implemented to explore their role in osteoarthritis events and regulation. Gross and microscopic results revealed curative effects of the extract on the osteoarthritis accompanied with improved immunoreactivity of the synovium. Data showed significant hormonal changes in different treated groups, indicating their role in osteoarthritis. In conclusion, the extract showed inhibitory effect on joint degradation and its earlier therapeutic application reflects importance of earlier treatment on the disease progression. Immunoreactivity as well as serum prostaglandins concentrations could be used as good markers to evaluate osteoarthritis events in the affected joints.
  F.J. Al-Saffar , S. Ganabadi , S. Fakurazi and H. Yaakub
  The main objective of this study was to elucidate the extent of hepatic oxidative stress following oral administration of zerumbone against monosodium iodoacetate induced Osteoarthritis (OA) in rats by monitoring microsomal cytochrome P450 and glutathione S-transferase enzymes as well as determination of oxidative stress biomarkers i.e., glutathione and malondialdehyde. Forty rats were randomly assigned into five groups. Rats in the first and second groups were treated with two different doses of zerumbone. Rats in the third group (positive control) were given celecoxib whereas the fourth group (negative control) was given corn oil. Rats of the fifth group were untreated not induced with OA and were used as a basal group. Results showed significant induction of cytochrome P450 and glutathione S-transferase and insignificant changes in both glutathione and lipid peroxidation levels in zerumbone treated groups compared to corn oil and basal groups. Levels of ALT and AST in zerumbone treated groups were comparable to the level in the basal group indicating absence of liver damage. Prostaglandin E2 level significantly reduced following zerumbone administration. Safety profile of zerumbone in this study, attract new investigation to explore its advantageous effect on using higher dosage regimen and/or longer duration against OA or other disease.
  F.J. Al-Saffar , S. Ganabadi , S. Fakurazi , H. Yaakub and M. Lip
  The objective of this investigation was to evaluate chondroprotective effect of zerumbone, a purified compound of Zingiber zerumbet Smith against monosodium iodoacetate (MIA) induced knee osteoarthritis (OA) in the rat. The effect on the articular cartilage was examined and compared with celecoxib (Celebrex®), a Non-Steroidal Anti-Inflammatory Drug (NSAID). Forty adult male Sprague Dawley rats were divided into four groups (n=10 for each). All animals were injected with MIA intraarticularly in their right knee joints to induce OA. Rats from first and second groups were treated with zerumbone in a same dose but with two different concentrations. Rats in the third group were treated with celecoxib and served as positive control whereas the fourth group were treated with corn oil and served as negative control. Evaluation of OA changes in the knees was assessed with the aid of both radiography and histopathology score. Macroscopic as well as microscopic examinations revealed curative effect of zerumbone in a dose dependent manner on the osteoarthritic knee joints. Apart from this, our data also revealed very poor anti-OA property of celecoxib. We concluded that oral administration of zerumbone in a dose of 2 mL kg-1 b.wt. of 0.4% w/v diluted with corn oil for a period of 4 weeks has some chondroprotective effects.
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