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Articles by S. Falah
Total Records ( 2 ) for S. Falah
  Sulistiyani , S. Falah , W.T. Wahyuni , T. Sugahara , S. Tachibana and Syaefudin
  The research objective is to obtain the cellular mechanism(s) of Syzygium polyanthum leaves for its development into commercial herbal product for certain degenerative diseases. The approach was to conduct activity-guided fractionation of metabolite extracts based on the antioxidant and the apoptotic modulation activities using cultured cells. Antioxidant activity of the active fractions were screened using 1,1-diphenyl-2-picrylhydrazil (DPPH) free radical assay and thiobarbituric acid (TBA) assay. The cellular effects were investigated using cultures of HB4C5 human hybridoma and mouse colon 26 adenocarcinoma cells. The flavonoids extract which has the lowest IC50 value of 14.84 μg mL-1 for DPPH assay among other metabolites, was found to have significant cytotoxic effect on both HB4C5 and colon 26 cells. Specific assays for apoptosis using caspase 3-gene expression and annexin-V flow cytometry analyses, supported the effect of cell proliferation inhibition which was not due to apoptosis. Subsequent cell cycle analysis indicated that crude extract may induce cell cycle arrest of HB4C5 cells at G1 to S phase, whereas active compound fractions of flavonoids stacked the cell cycle at G2/M phase. These observations suggest that flavonoid extracts of Syzygium polyanthum posses active compound(s) with anti-proliferative effect. This is a new finding for therapeutic potential of Syzygium polyanthum leaves in Indonesian traditional medicines.
  S. Falah , T. Suzuki and T. Katayama
  Chemical constituents of the bark of Swietenia macrophylla King (Meliaceae) was investigated not only to develop further bark utilization but also to understand the biochemical function of the bark in the forest environment. A new phenylpropanoid-substituted catechin, namely, swietemacrophyllanin [(2R*,3S*,7"R*)-catechin-8,7"-7,2"-epoxy-(methyl 4",5"-dihydroxyphenylpropanoate)] (1) was isolated from the bark of S. macrophylla together with two known compounds, catechin (2) and epicatechin (3). The structure of 1 was elucidated by spectroscopic data and by comparison of the NMR data with those of catiguanins A and B, phenylpropanoid-substituted epicatechins. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity of the isolated compounds indicated that all of the three compounds have strong activity compared with trolox as a reference. Swietemacrophyllanin (1) had the strongest activity with a 50% inhibitory concentration (IC50) value of 56 μg mL-1.
 
 
 
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