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Articles by S. Chanda
Total Records ( 6 ) for S. Chanda
  Y. Vaghasiya , R. Nair and S. Chanda
  Methanol extracts of Piper longum L., Piper betle L., Piper attanuatum Buch-Ham. [type-2], Piper hymenophyllum Miq., Piper sarmentosum Roxb., Piper argyrophyllum L., Piper attanuatum Buch.-Ham. [type-1] and Piper chaba Hunter were checked for their antibacterial efficiency against 15 clinically important bacterial strains. Cefotaxime sodium (100 μg disc-1) was used as standard. Crude leaf powder suspensions of these 8 Piper species were also evaluated for acute and chronic anti-inflammatory study at a dose of 300 mg kg-1. Diclofenac sodium was used as the standard drug. Carrageenan and dextran models were studied for acute inflammation while cotton pellet-induced granuloma was used for chronic inflammation study. ANOVA followed by Dunnett’s t-test were employed for statistical analysis. Piper species showed better anti-inflammatory activity than antibacterial activity. Piper sarmentosum, Piper argyrophyllum, Piper longum, Piper betle and Piper chaba has biologically important properties and they should be further explored and the active principle should be elucidated in order to bring out the promising antibacterial and anti-inflammatory agent.
  Y. Vaghasiya , R. Nair and S. Chanda
  The present communication deals with some studies on the antibacterial, physico-chemical and phytochemical parameters of different extracts of Eucalyptus citriodora leaf. The antibacterial study was performed using the agar ditch method on some clinically important bacteria, namely Pseudomonas pseudoalcaligenes, Proteus vulgaris, Citrobacter freundii, Staphylococcus subflava, Bacillus megaterium, and Enterobacter aerogenes. Physico-chemical parameters namely water, methanol, 1,4-dioxane, DMF, acetone soluble extractives, total ash, melting point, and pH were determined according to pharmacopoeial procedures. Methanol gave the maximum extract while it was minimum in water. Phytochemical parameters were screened for alkaloids, tannins, cardiac glycosides, saponins, steroids and flavonoids. Tannins and flavonoids gave positive results, while steroids and glycosides were absent. The most susceptible bacteria was C. freundii, while the most resistant was P. vulgaris.
  S. Chanda , R. Dave and M. Kaneria
  The main goal of this study was to determine the antioxidant activity of twelve medicinal plants (Averrhoa carambola (Oxalidaceae), Buchanania lanzan (Anacardiaceae), Calophyllum inophyllum (Clusiaceae), Celastras peniculatus (Celastraceae), Clerodendron multiflorum (Verbenaceae), Luffa acutangula (Cucurbitaceae), Morinda citrifolia (Rubiaceae), Ocimum gratissimum (Lamiaceae), Paltophorum ferrugineum (Papillionaceae), Phyllanthus fraternus (Euphorbiaceae), Triumfetta rotundifolia (Tilliaceae), Ziziphus nummularia (Rhamnaceae) belonging to different families. Antioxidant activity was determined by using different methods like DPPH (2,2’-Diphynyl, 1-picrylhydrazyl) free radical scavenging assay, hydroxyl radical scavenging assay, superoxide anion radical scavenging assay and reducing capacity assessment. The plants were extracted individually by cold percolation method using different organic solvents (petroleum ether, acetone and methanol) depending on their polarity. Ascorbic acid was used as standard to determine DPPH free radical scavenging activity and reducing capacity assessment. Gallic acid was used as standard to determine hydroxyl radical scavenging activity and superoxide anion radical scavenging activity. Amongst the twelve plants studied, acetone and methanolic extract of Paltophorum ferrugineum showed the best radical scavenging activity and reducing capacity assessment.
  Y. Vaghasiya , R. Dave and S. Chanda
  The aim of the present study was to investigate total phenols and flavonoids content of 53 traditionally used medicinal plants of western region of India. The plants/plant parts were extracted by cold percolation method in acetone and methanol. Qualitative phytochemical analysis was done for various phytoconstituents like alkaloids, tannins, cardiac glycosides, steroids and saponins. Total phenol and flavonoid conent was quantitatively estimated. Total phenolic contents were determined by the Folin-Ciocalteus reagent method. Total phenolic content was expressed as GAE (Gallic Acid Equivalents). Total flavonoid content was determined by the aluminium chloride colorimetric method. Total flavonoid content was expressed as quercetin equivalents. Tannins were present in more number of plants followed by cardiac glycosides and steroids. The Mangifera indica showed highest phenolic content, maximum content being in the methanol extract followed by Strychnos nux-vomica, Origanum marjoram, The Aristolochia bracteolate showed highest flavonoid content, maximum content being in the acetone extract followed by Phyllanthus reticulates, Argemone mexicana. Many reports suggest a positive correlation between total phenolic content and antioxidant activity so it can be stated that the Mangifera indica may possess good antioxidant property because of its high phenolic content.
  Y. Vaghasiya and S. Chanda
  The aim of the present study was to evaluate antibacterial and antioxidant activity of different solvent extracts of Mangifera indica L. seeds. The seeds of Mangifera indica L. were successively extracted in petroleum ether, chloroform, ethyl acetate, acetone and methanol. All obtained extracts were evaluated for antimicrobial and free radical scavenging (DPPH) activity. The in vitro antimicrobial activity was done by agar disc diffusion method at a concentration of 600 μg disc-1 against 5 Gram-positive bacteria, 7 Gram-negative bacteria and 3 fungal strains. The antioxidant potential was evaluated using scavenging of DPPH radical. Maximum antibacterial activity was shown by methanol extract followed by acetone extract. Acetone (IC50 = 11 μg mL-1) and methanol (IC50 = 12 μg mL-1) extract also showed DPPH scavenging activity which was comparable with that of standard ascorbic acid (IC50 = 11.4 μg mL-1). This study has highlighted the potentiality of antibacterial and antioxidant properties of M. indica seeds.
  S. Chanda , M. Kaneria and R. Nair
  Aim of the present study was to screen thirteen plants for their in vitro antibacterial potentiality. The antibacterial activity of aqueous and methanolic extracts of the plants was evaluated against 5 microorganisms by agar well diffusion method. The screening experiments showed that 92% of the plants were active against gram positive bacteria while only 54% of plants were active against Gram negative bacteria. Amongst the 13 plants screened, Psoralea corylifolia showed best antibacterial activity and hence this plant was selected for further studies. The seed and aerial parts of Psoralea corylifolia was extracted successively using a series of various organic solvents. The antibacterial activity of these extracts was done against 5 microorganisms by agar disc diffusion method. All the extracts of seed and aerial parts were active against S. epidermidis and P. morganii while none of the extracts were active against A. fecalis. Maximum antibacterial activity was shown by dioxan extract of the seed. The present findings suggest that the dioxan extract of seed of P. corylifolia can be used as a promising novel antibacterial agent in the near future.
 
 
 
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