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Articles by S. Bragadeeswaran
Total Records ( 3 ) for S. Bragadeeswaran
  S. Bragadeeswaran , K. Ganesan and N. Sri Kumaran
  Ascidians are marine animals with a great ability to synthesize bioactive substances. This study examined the heamolytic potential of ascidians Polyclinum madrasensis and Phallusia nigra. Ascidians P. madrasensis and P. nigra were collected from Tuticorin, Southeast coast of India. The collected ascidians were extracted by methanol at room temperature. The solvents were removed under reduced pressure to give predominantly an aqueous suspension. The protein content of crude P. madrasensis showed 680 μg mL-1 and crude P. nigra showed 543 μg mL-1, respectively. In sodium dodecyl sulfate polyacrylamide gel electrophoresis crude protein of P. madrasensis showed 4 bands 20, 27, 37 and 50 kDa and P. nigra showed 3 bands 20, 37 and 50 kDa. In the hemolytic assay maximum activity 64 Hemolytic Unit was showed in human “B” erythrocytes by P. madrasensis extract and minimum 2 Hemolytic Unit in human ‘O’ erythrocytes by crude extract of P. madrasensis. In 1H-NMR spectrum the spectral signal at δ 8.1 and δ 7.9 indicates the presence of guanidine and thymidine containing alkaloid in P. madrasensis and P. nigra. Thus results proved that the ascidians have remarkable hemolytic compounds and further studies will fulfill for purification and structural elucidation of the compounds.
  S. Bragadeeswaran and S. Thangaraj
  Eel fish, Anguilla anguilla skin contains specialised glandular cells that produce mucins and substance with antimicrobial and noxious properties. In the present study, Anguilla anguilla was collected from Parangipattai coastal waters of Tamil Nadu, India. The crude and aqueous extract of mucus was studied for hemolytic assay on chicken blood and goat blood, antibacterial activity against shrimp culture pond pathogens viz., Pseudomonas aeruginosa, Vibrio parahemolyticus, Escherichia coli, Staphylococcus aerius, Salmonella typhi, Salmonella paratyphi, Klebsiella pneumonia, Klebsiella oxytoca, Proteous microbilus and Lactobacillus vulgaris. The maximum specific hemolytic unit of 16 HU was recorded in chicken blood and minimum of 2 HU against goat blood. Whereas the antibacterial activity, maximum zone of inhibition 10 mm and minimum of 1 mm were showed in Salmonella paratyphi and Staphylococcus aerius, respectively. This present study has revealed that preliminary assays indicated that eel fish mucus was an interesting source for hemolytic and antibacterial activity.
  S. Bragadeeswaran , K. Prabhu , S. Sophia Rani , S. Priyadharsini and N. Vembu
  Ipomoea pes-caprae is a medicinal plant used in many countries for the treatment of several ailments including inflammatory and algesic processes. The present study describes the antimicrobial, hemolytic, analgesic and anti-inflammatory effects of the methanolic extract obtained from flower parts of this plant. The results indicated that the methanolic extract) exhibited considerable antinociceptive activity against two classical models of pain in mice. Methanolic extract presented a calculated the value of 5 and 2 mg kg-1 of body weight, i.p. against tail flick test and also inhibited both phases of pain (tail flick and hot plate). The maximum for paw licking Aanalgesic Rresponse (AR) was recorded 4 in crude extract of Ipomoea pes-caprae flower extract after 45 min of administration and minimum of 1 AR showed 30 and 45 min after administration whereas minimum of 3 AR was recorded in 60 min, respectively. The methanolic extracts exhibited the considerable antimicrobial activity against human bacterial and fungal pathogens. Preliminary phytochemical analysis suggested the presence of steroids, terpenoids, alkaloids and flavonoids. These findings support, at least in part, the popular use of I. pes-caprae to treat dolorous processes.
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