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Articles by S. Zahedi Asl
Total Records ( 3 ) for S. Zahedi Asl
  M.R. Shahraki , E.Y. Palan Mony , S. Zahedi Asl , A.R. Sarkaki and A.R. Shahraki
  This study was designed to investigate the effects of aluminium in male Rat. The experiment was performed on four groups of male rats, with lateral ventricle cannulated. Test group received aluminium chloride in lateral ventricle. Two series received the same volume of (5.5 μL) of ACSF with pH = 3.4 and 7.2. Sham control did not receive any agent. At the end, serum FSH, LH and Testosterone in all groups were measured by RIA methods. Epididymis and vas deferense were dissected, cut, diluted and spermatozoa were counted. Data obtained were analysed by ANOVA and Tukey-test. The results were expressed as mean±SE and p<0.05 were considered significant. The results showed, FSH, LH, testosterone and spermatozoid count per gram of tissues in vas deferense and epididymis, were decreased significantly in the test group which received aluminium chloride compared with other groups (p<0.05). The results of this study indicate that toxic effect of aluminium can be exerted via central nervous system.
  A. Sarkaki , S. Zahedi Asl and R. Assaei
  Aim of this research was to study the effect of intrahippocampal injection of different doses of AlCl3 in adult male rats on active avoidance learning. Thirty five adult male Wistar rats (250-300 g) were used into five groups: (1) Control, (2) Test-I received daily 1 μL AlCl3 1%, pH = 7.2, 3); Test-II received daily 1 μL AlCl3 0.5%, pH = 3.4, 4); Sham-I received daily 1 μL aCSF, pH = 7.2, 5); Sham-II received daily 1 μL aCSF, pH = 3.4. All rats in test and sham groups treated 10 min before training. Animals were anaesthetized with ketamine HCl/xylazine (90/10 mg kg-1 b.wt-1, i.p.) and underwent a stereotaxic surgery for implant of two stainless steel guide cannula into the hippocampus bilaterally. Every day 10 min after above treatments all rats were used to assess the spatial learning performing using Y-maze. Criterion Correct Response (CCR) was 90% in last session of training. There were no significant differences between training sessions to receiving CCR in control, Sham-I and Sham-II groups. Cognition in animals received AlCl3 1%, pH = 7.2 was impaired significantly with compare to other groups (*p<0.0001). Present results show that intrahippocampal injection of AlCl3 1%, causes active avoidance learning impairment significantly. The exact mechanism of Al3 effect on brain and cognition is remains unknown.
  M. Malek , S. Zahedi Asl , A. Sarkaki , Y. Farbood and A.H. Doulah
  The aim of this study was to evaluate the effect of intra-hippocampal injection of Growth Hormone (GH) on impaired spatial cognition in rats with Alzheimer’s Disease (AD). Growth hormone replacement therapy leading to improved cognition and well-being has mainly been carried in GH-deficient patients. Neverthelss, relatively only a few studies have investigated the function of GH in the brain. Aged Wistar male rats (350-400 g, 18-20 months old) were randomly divided into 6 groups (7 in each): Control (healthy aged); L; L+Veh; L+GH10; L+GH20 and L+GH40. Rats with AD-like cognitive deficiency was induced by injection of ibotenic acid into Nucleus Basalis of Meynert (NBM) bilaterally (5 μg 0.5 μL-1, each side). A guide cannula was implanted in the right hippocampus under stereotaxic surgery for injection of human recombinant GH (10, 20 and 40 μg 2 μL-1, during 5 min, twice daily, 9:00 am and 3:00 pm, for 7 days). All rats were trained in Morris water maze to evaluate the spatial learning and memory. Escape latency, traveled distance to find hidden platform and percent time spent in gaol qudrant did not differ between L and L+Veh groups, while latency and distance were reduced significantly. But percent time spent in gaol quadrant (without hidden platform) was increased significantly in NBM-lesioned rats treated with GH (L+GH groups) dose dependently to compare with vehicle treated group. These results suggest that intra-hippocampal injection of GH to aged rats with dementia type of AD (with NBM lesioned) could improve spatial cognition.
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