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Articles by S. Subramanian
Total Records ( 6 ) for S. Subramanian
  S. Subramanian , D. Sathish Kumar and P. Arulselvan
  The objective of this study was to evaluate the wound healing potential of Aloe vera leaf gel in experimental rabbits. The ethanolic extract in the form of an ointment (10%) was used for evaluating the wound healing potential in an excision wound model. The prophylactic effect elicited by the extract in terms of wound contraction and related biochemical parameters strongly support the healing and sealing properties of Aloe vera leaf gel.
  P. Arulselvan and S. Subramanian
  In the present study, antihyperglycemic effect of oral administration of ethanolic extract of M. koenigii leaves (200 mg/kg/day) for 30 days on carbohydrate metabolizing enzymes in the liver and kidney of streptozotocin induced diabetic rats was evaluated. Glibenclamide was used as a standard reference drug. Significant increase in blood glucose and glycosylated hemoglobin and a concomitant decrease in the levels of insulin and liver glycogen were observed in diabetic rats. Increased activities of lactate dehydrogenase, glucose-6-phosphatase, fructose-1,6-diphosphatase and glycogen phosphorylase and decreased activities of hexokinase, pyruvate kinase and glycogen synthase were observed in diabetic rats. These alterations were restored to near normal in the liver and kidney after treatment with M. koenigii leaf extract indicating that the therapeutic role of M. koenigii leaves in moderate streptozotocin induced diabetes.
  R.T. Narendhirakannan , S. Subramanian and M. Kandaswamy
  In the present study, anti-oxidant effect of ethanolic extract of Cleome gynandra leaves on the components of immune system in adjuvant induced experimental rats was evaluated. Freund’s Complete Adjuvant (FCA) was used to induce arthritis in experimental rats. Levels of Lipid peroxides (LPO) and activities of Superoxide dismutase (SOD), catalase, Glutathione peroxidase (GPx) and reduced glutathione (GSH) were evaluated in the lymphocytes, spleen and thymus of control and experimental rats. Further, the levels of ROS such as, hydroxy radicals, superoxide radicals and hydrogen peroxide (H2O2) were also measured in spleen, thymus and lymphocytes in experimental rats. Paw volume was also measured in the experimental animals. A significant increase in the levels of LPO, ROS and decreased activities of antioxidant enzymes in arthritic rats were observed. The above changes were reverted to near normal in Cleome gynandra leaf extract treated rats. The biologically active compounds such as, terpenes, flavonoids, saponins, steroids, phenolic compounds, alkaloids, carotenes, vitamins, minerals etc., which are present in C. gynandra leaves might be responsible for its anti-oxidant properties. The results demonstrated that anti-oxidant and anti-arthritic potent of C. gynandra leaves.
  G.P. Senthilkumar and S. Subramanian
  Impairment of mitochondrial function is intrinsically related with diabetes. Treatment strategies that focus on enhancing mitochondrial function are the important options for diabetes management. The present study was aimed to evaluate the protective effect of Terminalia chebula (T. chebula) fruits on mitochondrial damage in STZ-induced diabetic rats. Oral administration of ethanolic extract of the fruits (200 mg kg-1 body weight day-1) for 30 days significantly increased the activities of mitochondrial enzymes in diabetic rats. Transmission Electron Microscopic (TEM) observations also provided an additional strength to the prophylactic activity of fruit extract. Thus it may be concluded that the presence of biologically active ingredients in the fruit extract of T. chebula potentiate its anti-diabetic properties by regulating the mitochondrial enzymes.
  P. Arulselvan and S. Subramanian
  The objective of the present study is to evaluate the antioxidant potential of ethanolic extract of Murraya koenigii leaf on enzymatic, non enzymatic antioxidants and ultrastructural changes in liver of streptozotocin (STZ) induced diabetic rats. Effect of oral administration of M. koenigii leaves extract (200 mg kg-1 body weight) on the levels of blood glucose, plasma insulin, glycosylated hemoglobin, Thiobarbituric Acid Reactive Substances (TBARS), hydroperoxides, enzymatic and non-enzymatic antioxidants were estimated in STZ induced diabetic rats. Ultrastructural changes in the liver were also examined. Glibenclamide was used as a standard drug. The elevated levels of blood glucose, glycosylated hemoglobin, TBARS, hydroperoxides and decreased level of insulin observed in diabetic rats were significantly altered after treatment with the M. koenigii. The altered enzymatic and non-enzymatic antioxidants in the liver of streptozotocin induced diabetic rats, were restored to near normal levels by treatment with the M. koenigii leaves extract. Ultrastructure analysis of the liver of diabetic rat revealed a reduction in the Rough Endoplasmic Reticulum (RER) and swelling of mitochondria in the hepatocytes and these abnormalities were restored to near normal morphology by the treatment of rats with M. koenigii leaf extract. Our results suggested that the ethanolic extract of M. koenigii possess potent antioxidant properties which may be due to the presence of biologically active ingredients such as carbazole alkaloids, glycosides, triterpenoids and phenolic compounds. Thus the hepatoprotective and antidiabetic properties of M. koenigii leaves were probably of its antioxidant property.
  D. Shanthakumari , S. Srinivasalu and S. Subramanian
  Occurrence of fluorine in ground water has drawn worldwide attention due to its considerable impact on human physiology. In the present study the fluoride concentration in underground water was determined in four panchayats of Vellore district of Tamil Nadu State (India) where it is the only source of drinking water. The other water quality parameters such as pH, electrical conductivity, total dissolved salts, total hardness, total alkalinity as well as sodium, potassium, calcium, magnesium, chloride and sulphate concentrations were also measured. The analytical results indicated considerable variations among the analyzed samples with respect to their chemical composition. The fluoride concentration in the underground water of these villages varied from 0.43 to 4.59 mg L-1, causing dental and skeletal fluorosis. Overall water quality was found unsatisfactory for drinking purposes without any prior treatment. The prevalence of dental and skeletal fluorosis was determined among the people of Narasingapuram panchayat of Alangayam block, Vellore district, where the fluoride concentration in drinking water ranges from 2.35 to 4.59 ppm. The study further revealed that male individuals are more prone to dental and skeletal fluorosis than the female individuals.
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