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Articles by S. Shantha Kumar
Total Records ( 1 ) for S. Shantha Kumar
  D. Sivaraman , S. Shantha Kumar , P. Muralidharan and Habibur Rahman
  Background: To investigate the effect of Methanol root extract of Hemidesmus indicus (MEHI) on cerebral infract by four vessel occlusion method. Method: A total of 36 Sprague-Dawley (SD) rats were studies. In the present study the animals were pretreated with MEHI for a period of 1week (200 and 400 mg kg-1) p.o. Cerebral ischemia was established by permanent occlusion of vertebral artery followed by 15 min occlusion of bilateral carotid arteries. After 24 h of reperfusion the animal behavior were evaluated for neuromuscular function, vestibulomotor function and complex neuromotor function. The treatment was continued for another week after surgery with root extract and the animals were sacrificed and the brain was removed and homogenized. The homogenized content was used for the estimation of anti-oxidant enzymes and various neurotransmitter levels. Results: The group treated with 200 and 400 mg kg-1 MEHI showed significant (p<0.01) improvement in neuromuscular, vestibulomotor, complex neuromuscular function when compared with negative control group. Significant increase in brain anti oxidant enzymes was observed in MEHI treated group when compared to negative control. The MEHI treated groups exhibited a significant decrease in the levels of acetyl choline esterase, glutamate and monoamine oxidase-B. Increased levels of dopamine and serotonin were observed in the treated group when compared with ischemic group. Conclusion: MEHI can improve the neurological status and may reduce the cerebral infract in ischemia-reperfusion injured rats.
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