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Articles by S. S Wang
Total Records ( 2 ) for S. S Wang
  S. S Wang , L. J Martin , E. E Schadt , H Meng , X Wang , W Zhao , L Ingram Drake , M Nebohacova , M Mehrabian , T. A Drake and A. J. Lusis
 

Background— Disruption of the elastic lamina, as an early indicator of aneurysm formation, and vascular calcification frequently occur together in atherosclerotic lesions of humans.

Methods and Results— We now report evidence of shared genetic basis for disruption of the elastic lamina (medial disruption) and medial calcification in an F2 mouse intercross between C57BL/6J and C3H/HeJ on a hyperlipidemic apolipoprotein E (ApoE–/–) null background. We identified 3 quantitative trait loci (QTLs) on chromosomes 6, 13, and 18, which are common to both traits, and 2 additional QTLs for medial calcification on chromosomes 3 and 7. Medial disruption, including severe disruptions leading to aneurysm formation, and medial calcification were highly correlated and occurred concomitantly in the cross. The chromosome 18 locus showed a striking male sex-specificity for both traits. To identify candidate genes, we integrated data from microarray analysis, genetic segregation, and clinical traits. The chromosome 7 locus contains the Abcc6 gene, known to mediate myocardial calcification. Using transgenic complementation, we show that Abcc6 also contributes to aortic medial calcification.

Conclusions— Our data indicate that calcification, though possibly contributory, does not always lead to medial disruption and that in addition to aneurysm formation, medial disruption may be the precursor to calcification.

  K. Q Yan , S. S Wang and S. C. Wang
 

Generally, tasks in a distributed system must reach agreement. This requires a set of processors to agree on a common value even though some components may be corrupt. There have been several significant studies on this agreement problem in regularized network environments such as the fully connected, broadcast and multicast networks. Recently, many large complex networks have emerged displaying a scale-free feature that influences the system to reach a common value in a novel way. This unanimity problem is called Byzantine agreement (BA). The BA problem is one of the most significant problems in designing a fault-tolerant distributed system. Unfortunately, existing BA protocols cannot cope with the new network environment, and the BA problem thus must be revisited. In this paper, a new BA protocol is proposed that adapts to the scale-free network (SFN) environment and derives its limit of allowable faulty components while maintaining the minimum number of message exchanges. The correctness and complexity of this protocol have been proved. It is observed that an SFN in conjunction with the proposed agreement protocol can tolerate the maximum number of faulty components.

 
 
 
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