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Articles by S. Lance Macaulay
Total Records ( 2 ) for S. Lance Macaulay
  Maria C. Carrillo , Christopher C. Rowe , Cassandra Szoeke , Colin L. Masters , David Ames , Tim O’Meara , S. Lance Macaulay , Andrew Milner , Kathryn A. Ellis , Paul Maruff , Stephanie R. Rainey- Smith , Ralph N. Martins , Lisa J. Bain and Richard J. Head
  Alzheimer's disease (AD) is an epidemic facing the entire world. Increased knowledge gained during the past 25 years indicates that AD falls along a clinical and neuropathological spectrum represented as a continuum that extends from preclinical disease in which there are no symptoms, through early symptomatic phases, and finally to AD dementia. The Alzheimer's research community recognizes that imaging, body fluids, and cognitive biomarkers contribute to enhanced diagnostic confidence for AD. There has also been emerging consensus regarding the use of AD biomarkers in clinical trials. The use of biomarkers in clinical trials and practice is hampered by the lack of standardization. In response to the emerging need for standardization, an international meeting of AD researchers was held in Melbourne, Australia, in March 2012 to bring together key researchers, clinicians, industry, and regulatory stakeholders with the aim of generating consensus on standardization and validation of cognitive, imaging, and fluid biomarkers, as well as lifestyle parameters used in research centers worldwide.
  Tristan J. Iseli , Jonathan S. Oakhill , Michael F. Bailey , Sheena Wee , Mark Walter , Bryce J. van Denderen , Laura A. Castelli , Frosa Katsis , Lee A. Witters , David Stapleton , S. Lance Macaulay , Belinda J. Michell and Bruce E. Kemp
  AMP-activated protein kinase (AMPK) plays multiple roles in the body`s overall metabolic balance and response to exercise, nutritional stress, hormonal stimulation, and the glucose-lowering drugs metformin and rosiglitazone. AMPK consists of a catalytic α subunit and two non-catalytic subunits, β and γ, each with multiple isoforms that form active 1:1:1 heterotrimers. Here we show that recombinant human AMPK α1β1γ1 expressed in insect cells is monomeric and displays specific activity and AMP responsiveness similar to rat liver AMPK. The previously determined crystal structure of the core of mammalian αβγ complex shows that β binds α and γ. Here we show that a β1(186–270)γ1 complex can form in the absence of detectable α subunit. Moreover, using alanine mutagenesis we show that β1 Thr-263 and Tyr-267 are required for βγ association but not αβ association.
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