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Articles by S. Koduru
Total Records ( 2 ) for S. Koduru
  S. Koduru , D.S. Grierson and A.J. Afolayan
  Solanum aculeastrum is a medicinal plant that showed low seed germination under laboratory conditions. The objective of this study was to establish whether germination could be improved by the exposure of its seeds to high temperatures such as those registered on surface soils during natural fires. Our results indicated that temperatures of 100 and 120°C applied to green mature seeds of S. aculeastrum, for 45 to 60 min may break their innate dormancy, thus stimulating their subsequent germination to more than 85%. Germination in dry seeds, however, showed very low germination when subjected to high temperatures. Where the effect of smoke was tested on the germination of the green mature and dry seeds of S. aculeastrum, no stimulation of germination was observed. The ecological implications of these observations are discussed.
  S. Koduru , D.S. Grierson , M. van de Venter and A.J. Afolayan
  Solanum aculeastrum is a medicinal plant used by the traditional healers of the Eastern Cape of South Africa, for the treatment of cancers. The antiproliferative activities of this plant were studied in vitro using three human tumour cell lines (HeLa, MCF7 and HT29). Methanolic extracts of the fruits had the highest antiproliferative activity with IC50 between 17.1 and 41.9 μg mL-1 while the activities of their aqueous extracts ranged between 27.9 and 48.5 μg mL-1. The leaf extracts had no anticancer activity under the experimental conditions tested. Overall, the HeLa and MCF7 cell lines were much more sensitive to both extracts than HT29 cells.
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