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Articles by S. Justin Raj
Total Records ( 10 ) for S. Justin Raj
  Baby Joseph , S. Justin Raj , Biby. T. Edwin and P. Sankarganesh
  Snake venom is a special liquid which is produced by the poison gland of the poisonous snake. Snake venoms generally consist of a complex mixture of substances, each of which may exhibit one or more distinct toxic actions. Many of these proteins are harmless to humans but some are toxic. Snake venoms effects include, anti-blood coagulation, neurotoxicity, mycotoxicity, nephrotoxicity, cardiotoxicity and necrotoxicity. Snake venom is hemolytic and neuropathic-type venom. The hemolysis venom is more effective than the neuropathic-type venom and it will work almost immediately to the prey. According to traditional system of medicine, snake venom is widely used in various disorders in skin and blood. It performs good antitumor activity. This study reports on its traditional, chemical and pharmacological properties such as antioxidant, anticancer and analgesic activity.
  Baby Joseph and S. Justin Raj
  The present investigation was carried out to understand the impact of curacron on Serum aminotransferases activity (ALT and AST) of fresh water fish Cyprinus carpio. Curacron is an organophosphate pesticide and is widely used by the farmers to protect their crops. So every year huge volume of Curacron enters to aquatic ecosystems. The objective of this study was to determine the effect of curcuron pesticides and its influence of serum biomarker enzyme (ALT and AST). LC50 of Curacron for Cyprinus carpio has been calculated by the log-dose/probit regression line method and recorded as 0.38 ppm at 96 h. Three sub-lethal concentrations (0.1, 0.01 mL and 0.001 ml L-1) were selected to expose the fish for 1, 7, 14 and 21 days. Changes in enzyme activity were observed with all concentrations and exposure period. ALT and AST concentrations were significantly higher in the experimental group, compared with the control group. The above results of blood plasma profile indicate a marked cytotoxic and hepatotoxic effect of curacron in Cyprinus carpio.
  Baby Joseph , P. Sankarganesh , Biby T. Edwin and S. Justin Raj
  Endophytic Streptomycetes are the most exploited group in the medicinal and agro based industries. In this review, we correlated recently identified its bioactive compounds with plant chemical structures. Booming the global warm is the important problem to increase the alternative research initiatives for green chemicals. During long genetic co-evaluation with plants Streptomycetes have created novel and interesting chemistry. Their ability to produce plant related chemicals has increased its importance. It also reduces the need of harvesting plants for drug. Specific approaches from ethanobotanical valued plants with medicinal applications could be the key to isolating bioactive compound producing strains.
  Baby Joseph , Biby T. Edwin , Boby T. Edwin , S. Justin Raj and P. Sankarganesh
  Bone Marrow Mesenchymal Stem Cells (BMMSCs) are a group of non-hematopoietic cells residing within the bone marrow. These are adhesive cells which can differentiate into osteogenic, adipogenic and chondrogenic lineages under appropriate conditions, results in maintaining the homeostasis mechanism. Though extracellular matrix is meant only for MSCs cell adhesion, it has some role in the lineage change. Apart from the extracellular matrix, growth factors play a pivotal role in the morphogenesis. In this review, we discuss the characteristics of BMMSCs, their differentiation potential toward different skeletal tissues (cartilage and bone) and bone tissue engineering and its need.
  Baby Joseph and S. Justin Raj
  Indian traditional medicines based on various systems including Ayurveda, Siddha, Unani and Homeopathy. The evaluation of these drugs is primarily based on phytochemical, pharmacological properties. plants have been an exemplary source of medicine. Ayurveda and other Indian literature mention the use of plants in treatment of various human ailments. In traditional system of medicine various plant parts such as stem bark, root bark aerial roots, vegetative buds, leaves, fruits and latex are used in dysentery, diarrhoea, diabetes leucorrhoea, menorrhagia, dropsy, jaundice, diarrhoea, dysentery, intermittent fevers, diseases of urino-genital system, scabies, ulcers,wounds, cold, nervous disorders and as tonic. Medicinal plants are popular in indigenious system of medicine like ayurveda, siddha, unani and homoeopathy and is used for its hepatoprotective, antitumour, antidiabetic, antihypertensive, analgesic, anti-inflammatory and antimicrobial properties. The present review is therefore, an effort to give a comparative study on its properties of five medicinally important plants.
  Baby Joseph and S. Justin Raj
  Modern agricultural practices result in indiscriminate use of various agrochemicals, which usually enter into the aquatic environment. The use of agrochemicals in the field has the potential to change the aquatic medium, affecting the tolerance limit of aquatic fauna and flora, as well as creating danger to the ecosystem. These agrochemicals adversely affect the non-target organisms, especially plankton and fish. The present study reports the acute and sublethal toxicity of pesticides on plasma protein, acetylcholinesterase, hormones, histopathology, changes in gill, ventillatory frequency and stress protein level of freshwater fishes. The alterations of the hormonal levels may be used as a potential biomarker and also can establish the ability of endocrine tissues to respond to their appropriate releasing factors. Heat Shock Proteins (HSPs) are detected in all cells, prokaryotic and eukaryotic. In vivo and in vitro studies have shown that various stressors transiently increase production of HSPs as protection against harmful insults. Increased levels of HSPs occur after environmental stresses, infection, normal physiological processes and gene transfer.
  S. Justin Raj and Baby Joseph
  Experiment was conducted on fish, Oreochromis mossambicus to study the effect of acetamiprid on tissue biomarker lactate dehydrogenase. Acetamiprid is a neonicotinoid pesticide and it is used by the farmers to protect their crops. This pesticide residue reaches to the aquatic ecosystem by many ways and affects the aquatic fauna. Lethal Concentration (LC50) of acetamiprid for O. mossambicus has been calculated by probit analysis and recorded as 5.99 ppm at 96 h. Chronic exposure shows increased activity of LDH in liver, brain and gill tissues during all the exposure periods when compared with the control. This significant increase in enzyme activity was observed due to toxic effect of acetamiprid. Long term exposure of organisms to pesticides means a continuous health hazard for the fish population and it is on high risk by consuming these toxicated fishes.
  S. Justin Raj and Baby Joseph
  The study analyze the effect of pesticide-acetamiprid on protein content and carbohydrate content of liver, brain and gill tissues of Oreochromis mossambicus. Acetamiprid is an neonicotinoid pesticide and is used by the farmers to protect their crops. Pesticides may enter water bodies as a result of spray drift and leaching from the soil in concentrations, which may exert adverse effects on fish populations. Lethal concentration (LC50) of acetamiprid for O. mossambicus has been calculated by probit analysis and recorded as 5.99 ppm at 96 h. Chronic exposure shows decreased protein and carbohydrate content in liver, brain and gill tissues during all the exposure periods when compared with the control. This significant decrease in protein and carbohydrate content was observed due to toxic effect of acetamiprid. Long term exposure of organisms to pesticides means a continuous health hazard for the fish population and it is on high risk by consuming these toxicated fishes.
  Baby Joseph , Biby T. Edwin , Boby T. Edwin , P. Sankarganesh and S. Justin Raj
  Biomaterials are one of the active research areas in tissue engineering due to its high demand in regenerative medicine. And it plays a crucial role in mesenchymal stem cells therapy. A number of biomaterials and their combinations are available for the production of artificial extracellular matrix for skeletal repair like demineralised bone matrixes, polymers, bioactive glasses, coral, bioactive ceramics but unfortunately the design of scaffolds for bone tissue engineering presents several difficulties. The focus of this article is a brief narration of commonly used biomaterials for scaffold making for bone tissue engineering.
  Baby Joseph and S. Justin Raj
  The experiment was conducted on fish, Cyprinus carpio to study the effect of curacron on serum biomarker (LDH). Curacron is a organophosphate pesticide and is used by the farmers to protect their crops. This pesticide reaches to the aquatic ecosystem by many ways and affects the aquatic fauna. LC50 of Curacron for Cyprinus carpio has been calculated by the log-dose/probit regression line method and recorded as 0.38 ppm at 96 h. Three sub-lethal concentrations (0.1, 0.01 mL and 0.001 ml L-1) were selected to expose the fish for 1, 7, 14 and 21 days. Changes in enzyme activity were observed with all concentrations and exposure period. Lactate concentrations were significantly lower in the experimental group, compared with the control group. The above results of blood plasma profile indicate a marked cytotoxic and hepatotoxic effect of curacron in fishes.
 
 
 
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