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Articles by S. H Wild
Total Records ( 2 ) for S. H Wild
  F Marroni , A Pfeufer , Y. S Aulchenko , C. S Franklin , A Isaacs , I Pichler , S. H Wild , B. A Oostra , A. F Wright , H Campbell , J. C Witteman , S Kaab , A. A Hicks , U Gyllensten , I Rudan , T Meitinger , C Pattaro , C. M van Duijn , J. F Wilson , P. P Pramstaller and on behalf of the EUROSPAN Consortium
 

Background— We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations.

Methods and Results— We analyzed the heart rate at rest, measured as the RR interval, and the length of the corrected QT interval for association with 318 237 single-nucleotide polymorphisms. The RR interval was associated with common variants within GPR133, a G-protein–coupled receptor (rs885389, P=3.9x10–8). The QT interval was associated with the earlier reported NOS1AP gene (rs2880058, P=2.00x10–10) and with a region on chromosome 13 (rs2478333, P=4.34x10–8), which is 100 kb from the closest known transcript LOC730174 and has previously not been associated with the length of the QT interval.

Conclusion— Our results suggested an association between the RR interval and GPR133 and confirmed an association between the QT interval and NOS1AP.

  N. L. M Cruden , S. A Harding , A. D Flapan , C Graham , S. H Wild , R Slack , J. P Pell , D. E Newby and on behalf of the Scottish Coronary Revascularisation Register Steering Committee
  Background—

Noncardiac surgery performed after coronary stent implantation is associated with an increased risk of stent thrombosis, myocardial infarction, and death. The influence of stent type and period of risk still have to be defined.

Methods and Results—

We linked the Scottish Coronary Revascularisation Register with hospital admission data to undertake a Scotland-wide retrospective cohort study examining cardiac outcomes in all patients who received drug-eluting or bare-metal stents between April 2003 and March 2007 and subsequently underwent noncardiac surgery. Of 1953 patients, 570 (29%) were treated with at least 1 drug-eluting stent and 1383 (71%) with bare-metal stents only. There were no differences between drug-eluting and bare-metal stents in the primary end point of in-hospital mortality or ischemic cardiac events (14.6% versus 13.3%; P=0.3) or the secondary end points of in-hospital mortality (0.7% versus 0.6%; P=0.8) and acute myocardial infarction (1.2% versus 0.7%; P=0.3). Perioperative death and ischemic cardiac events occurred more frequently when surgery was performed within 42 days of stent implantation (42.4% versus 12.8% beyond 42 days; P<0.001), especially in patients revascularized after an acute coronary syndrome (65% versus 32%; P=0.037). There were no temporal differences in outcomes between the drug-eluting and bare-metal stent groups.

Conclusions—

Patients undergoing noncardiac surgery after recent coronary stent implantation are at increased risk of perioperative myocardial ischemia, myocardial infarction, and death, particularly after an acute coronary syndrome. For at least 2 years after percutaneous coronary intervention, cardiac outcomes after noncardiac surgery are similar for both drug-eluting and bare-metal stents.

 
 
 
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