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A cross-sectional study was conducted in a group of 880 workers employed in industries workers south of Tehran. Pulmonary function test was measured among 224 of suspected respiratory abnormalities workers. In pulmonary function test of subjects, 147(68.0%) had normal while 77 (32.0%) showed reduced. There were statistically significant differences between mean measured and predicted values in terms of FEV1 and FVC (p<0.0001), PEFR (p<0.006). The highest percent of respiratory disorders were among workers food, drink, tobacco, construction and metal industries with 24.7, 20.8 and 18.1%, respectively. It is recommended that engineering measures be adopted to reduce the harmful materials in industries, together with health monitoring of exposed employees. All workers who are exposed to harmful materials should be given regularly scheduled lung function tests. This exam is a valuable tool in a full program for detecting and preventing serious occupational lung diseases.