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Articles by S. Emmanuel Joshua Jebasingh
Total Records ( 1 ) for S. Emmanuel Joshua Jebasingh
  S. Emmanuel Joshua Jebasingh and A. Murugan
  Background: Marine bacteria Bacillus megaterium associated with cone snail and Pseudomonas aeruginosa from tubeworm were cultured and the chloroform extract of the culture supernatants were screened for Central Nervous System (CNS) depressant, anti-inflammatory, analgesic and antipyretic activities. Results: The locomotor activity in rats was greatly reduced by both extracts and the activity was dose dependent. The B. megaterium strain extract showed higher depressant activity. Though the groups treated with test extracts of B. megaterium and P. aeruginosa showed increase in volume of paw edema, anti-inflammatory activity was noticed up to 30 min except in P. aeruginosa 200. B. megaterium extract at 200 mg kg-1 was potent as it showed higher activity even at 60 min than the standard drug. In analgesic activity screening, the reaction time increased with increasing extract concentration and time. Both extracts produced significant antipyretic effect in a dose dependant manner. The CNS depressant and analgesic activities were pronounced in both extracts. The chloroform extract of B. megaterium and P. aeruginosa shows significant pharmacological activities. The chloroform extract of both strains showed potent to Central Nervous System depressant, anti-inflammatory, analgesic and antipyretic activities.
 
 
 
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