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Articles by S. A Wood
Total Records ( 3 ) for S. A Wood
  N Matigian , G Abrahamsen , R Sutharsan , A. L Cook , A. M Vitale , A Nouwens , B Bellette , J An , M Anderson , A. G Beckhouse , M Bennebroek , R Cecil , A. M Chalk , J Cochrane , Y Fan , F Feron , R McCurdy , J. J McGrath , W Murrell , C Perry , J Raju , S Ravishankar , P. A Silburn , G. T Sutherland , S Mahler , G. D Mellick , S. A Wood , C. M Sue , C. A Wells and A. Mackay Sim
  Nicholas Matigian, Greger Abrahamsen, Ratneswary Sutharsan, Anthony L. Cook, Alejandra M. Vitale, Amanda Nouwens, Bernadette Bellette, Jiyuan An, Matthew Anderson, Anthony G. Beckhouse, Maikel Bennebroek, Rowena Cecil, Alistair M. Chalk, Julie Cochrane, Yongjun Fan, Francois Feron, Richard McCurdy, John J. McGrath, Wayne Murrell, Chris Perry, Jyothy Raju, Sugandha Ravishankar, Peter A. Silburn, Greg T. Sutherland, Stephen Mahler, George D. Mellick, Stephen A. Wood, Carolyn M. Sue, Christine A. Wells, and Alan Mackay-Sim There is a pressing need for patient-derived cell models of brain diseases that are relevant and robust enough to produce the large quantities of cells required for molecular and functional analyses. We describe here a new cell model based on patient-derived cells from the human olfactory mucosa, the organ of smell, which regenerates throughout life from neural stem cells. Olfactory mucosa biopsies were obtained from healthy controls and patients with either schizophrenia, a neurodevelopmental psychiatric disorder, or Parkinson’s disease, a neurodegenerative disease. Biopsies were dissociated and grown as neurospheres in defined medium. Neurosphere-derived cell lines were grown in serum-containing medium as adherent monolayers and stored frozen. By comparing 42 patient and control cell lines we demonstrated significant disease-specific alterations in gene expression, protein expression and cell function, including dysregulated neurodevelopmental pathways in schizophrenia and dysregulated mitochondrial function, oxidative stress and xenobiotic metabolism in Parkinson’s disease. The study has identified new candidate genes and cell pathways for future investigation. Fibroblasts from schizophrenia patients did not show these differences. Olfactory neurosphere-derived cells have many advantages over embryonic stem cells and induced pluripotent stem cells as models for brain diseases. They do not require genetic reprogramming and they can be obtained from adults with complex genetic diseases. They will be useful for understanding disease aetiology, for diagnostics and for drug discovery.

  S. A Wood , M. J Prentice , K Smith and D. P. Hamilton
 

The relationship between heterocyte frequency, water temperature, nutrient concentrations and densities of Anabaena planktonica was examined in monomictic, eutrophic Lower Karori Reservoir (max. depth 21 m, area 0.034 km2), Wellington, New Zealand. Anabaena planktonica formed blooms and strongly dominated the phytoplankton assemblage during summer. The development of blooms of A. planktonica was associated with the set-up of stratification and increases in surface water temperature, with the peak of the bloom almost synchronous with maximum water temperature. The annual peak in heterocyte frequency preceded the bloom and occurred during a period of intensifying stratification. At this time, there were sustained low concentrations of dissolved inorganic nitrogen (DIN: nitrate-N + ammonium-N) and the lowest ratios of DIN to soluble reactive phosphorus (SRP), though ratios of total nitrogen to total phosphorus (TN:TP) were more variable. The apparent increase in nitrogen fixation capacity, based on increased heterocyte frequency, appears to be an important prerequisite to bloom formation for A. planktonica in the Lower Karori Reservoir. Monitoring heterocyte frequency may be a useful predictor for the occurrence of blooms of heterocytous cyanobacteria in eutrophic lakes due to the asynchronous nature of development of nitrogen limitation, heterocytes and vegetative cells.

 
 
 
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