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Articles by S Inomata
Total Records ( 2 ) for S Inomata
  T Shimizu , S Inomata and M. Tanaka
  Background

Progesterone has long been known to have central effects, by reduced anaesthetic requirements as measured by minimum alveolar concentration (MAC) in various settings. However, other studies have contradicted these findings. Therefore, we compared the effect of progesterone on anaesthetic requirements in a mouse model.

Methods

Male C57BL/6 mice were treated with either progesterone (37.5 or 75 mg kg–1) or the olive oil vehicle, 1 h before each experiment. Animals were placed in a revolving cylinder (4 rev min–1) and supplied with oxygen and stepwise increasing concentrations of sevoflurane. The number of complete rollovers during revolution of the chamber was counted as a measure of anaesthetic requirement.

Results

S.C. administration of progesterone 75 mg kg–1 significantly reduced sevoflurane requirement (P<0.0001). Progesterone 37.5 mg kg–1 did not change sevoflurane requirement.

Conclusions

We conclude that administration of exogenous progesterone injection at higher concentrations decreases anaesthetic requirement as defined by rolling response.

  S Inomata , T Maeda , T Shimizu , T Satsumae and M. Tanaka
  Background

Sevoflurane can be used as a sole agent for intubation in children, but studies have suggested that it is associated with emergence agitation. Fentanyl infusions can be used both to facilitate intubation and decrease emergence agitation. We investigated the effects of fentanyl on conditions at intubation and on emergence from sevoflurane anaesthesia without confounding nitrous oxide or premedication.

Methods

IRB approval and informed consent were obtained. Subjects comprised 150 ASA physical status I or II (age, 2–6 yr). Anaesthesia was induced with sevoflurane in oxygen and maintained using a predetermined concentration of sevoflurane. Subjects were randomly allocated to receive one of three doses of fentanyl: vehicle only (control group), a bolus dose of 1 µg kg–1 followed by a continuous infusion of 0.5 µg kg–1 h–1 (F1 group), or a bolus dose of 2 µg kg–1 followed by a continuous infusion of 1 µg kg–1 h–1 (F2 group). Sevoflurane minimum alveolar concentration for tracheal intubation (MACTI) and emergence agitation score were assessed.

Results

MACTI values were 2.49%, 1.61%, and 1.16% in control, F1, and F2 groups, respectively (P<0.05). Agitation scores were 11.5, 7.0, and 2.6 in control, F1, and F2 groups, respectively (P<0.05).

Conclusions

Fentanyl infusion consisting of a bolus dose of 2 µg kg–1 followed by a continuous infusion of 1 µg kg–1 h–1 facilitates tracheal intubation and smooth emergence in children anaesthetized using sevoflurane.

Clinical trial registration: this study was started in 2000 and was finished in 2008. We had no registration number. IRB approval was obtained.

 
 
 
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