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Articles by S Al Khatib
Total Records ( 1 ) for S Al Khatib
  R Tachdjian , C Mathias , S Al Khatib , P. J Bryce , H. S Kim , F Blaeser , B. D O'Connor , D Rzymkiewicz , A Chen , M. J Holtzman , G. K Hershey , H Garn , H Harb , H Renz , H. C Oettgen and T. A. Chatila
 

Polymorphisms in the interleukin-4 receptor chain (IL-4R) have been linked to asthma incidence and severity, but a causal relationship has remained uncertain. In particular, a glutamine to arginine substitution at position 576 (Q576R) of IL-4R has been associated with severe asthma, especially in African Americans. We show that mice carrying the Q576R polymorphism exhibited intense allergen-induced airway inflammation and remodeling. The Q576R polymorphism did not affect proximal signal transducer and activator of transcription (STAT) 6 activation, but synergized with STAT6 in a gene target– and tissue-specific manner to mediate heightened expression of a subset of IL-4– and IL-13–responsive genes involved in allergic inflammation. Our findings indicate that the Q576R polymorphism directly promotes asthma in carrier populations by selectively augmenting IL-4R–dependent signaling.

 
 
 
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