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Articles by Rosdiana Natzir
Total Records ( 3 ) for Rosdiana Natzir
  Rosdiana Natzir
  Purified human α-1 microglobulin from the patients with Cadmium intoxication was also found in normal human urine and plasma with low concentration. On Agarose Gel Electrophoresis, human α-1 microglobulin from urine of the patients with tubular proteinuria caused Cadmium intoxication was found to have a low molecular weight of about 30 kDa. By used Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis or SDS-PAGE and subsequently transferred to the PVDF-membrane for Western-immunoblot analysis, the result showed a high molecular weight of protein (50-60 kDa) and then we so called the α-1microglobulin complex.
  Ressy Dwiyanti , Mochammad Hatta , Rosdiana Natzir , Sutji Pratiwi , Muhammad Sabir , Yadi Yasir , Rizki Amelia Noviyanthi , Ade Rifka Junita , Nataniel Tandirogang , Masyhudi Amir , Matius Fias , Juhri Saning and Burhanuddin Bahar
  Only small proportions of Salmonella enterica serovar Typhi (S. Typhi), in endemic areas, exposing individuals develop typhoid fever symptoms. Identification of polymorphisms NOD2, VDR and NRAMP1 genes is mandatory for a better understanding of typhoid fever molecular pathogenesis and thus to the development of novel strategies for the prevention of infection. The aim of this study was to determine whether genetic polymorphisms in nucleotide oligomerization binding domain 2 (NOD2), vitamin D receptor (VDR) gene and natural resistance-associated macrophage protein 1 (NRAMP1) genes are involved in host susceptibility to severity of typhoid fever. The genotyping of eight regions were applied in the genes; NOD2, VDR and NRAMP1, using PCR-RFLP. A multivariate analysis on 426 mild and 35 severe state of typhoid fever patients. All patients living in the geographically isolated village of South Sulawesi, Middle Sulawesi, Southeast Sulawesi, East Borneo and Papua islands which was an endemic areas in Indonesia. Data were analyzed using Microsoft Excel and Stata 9.2. The G/C and C/C alleles of exon 8 in NOD2 gene were strongly associated and more frequently found in the patients with severe typhoid fever than in mild typhoid fever (p= 0.027and 0.014, odds ratio = 16.7and 27.9, 95% confidence interval = 3.4 - 25.7and 2.6 - 37.1in G/C allele and C/C allele), respectively. In contrast, No evidence for the association of VDR and NRAMP1 genes polymorphisms with severity state of typhoid fever. The polymorphism of exon 8 in NOD2 gene; heterozygotes or homozygotes for a G→C change in codon 2722, was related to susceptibility to typhoid fever in clinical severity of this disease. Polymorphisms of exon 8 in NOD2 gene; heterozygotes or homozygotes for G/C in codon 2722 were related to susceptibility to typhoid fever in clinical severity.
  Wahyudin , Muh Nasrum Massi , Rosdiana Natzir , Gemini Alam and Agus Salim Bukhari
  Background and Objective: The state of obesity is closely related to insulin resistance, which leads to type 2 diabetes. Free Fatty Acids (FFAs) play a role in the development of insulin resistance. Artocarpus altilis plants have traditionally been used by the people of Indonesia for the treatment of diabetes mellitus. This study aimed to determine the concentrations of A. altilis leaf extract that can improve insulin resistance in obese rats (Rattus norvegicus) through identification of the concentrations that can decrease the levels of FFA. Methodology: This study is a Randomized Controlled Trial (RCT). The rats were divided into five groups, each consisting of five rats. The rats were administered a high-fat diet (45%) (open source) to induce fattening and their weights were measured for assessing obesity. The fasting blood sugar (GDP) was monitored through gluco DR tests to ensure that the mice exhibited an increased glucose concentration. Group I was designated the negative control group, the rats in group II were administered metformin HCl and formed the positive control group and groups III, IV and V were denoted the 5, 10 and 15% A. altilis test groups. The groups underwent treatment for 14 days and ELISA was performed for the assessment of the FFA levels in each group after testing. A data analysis using nonparametric tests was performed to assess the significance of the differences among the groups at a 95% confidence level. All of the data were analyzed with SPSS version 21.0 (SPSS, Inc., Chicago, IL, USA). Results: The FFA levels in the negative control and the10% A. altilis (p = 0.000) and 15% A. altilis (p = 0.016) extracts did not show any significant differences, differences in the FFA content were found between the positive control and the 5% A. altilis (0.034) and 10% A. altilis (p = 0.020) test groups. Conclusion: The 10% A. altilis extract can lower the FFA levels in obese mice. Therefore, A. altilis should be considered for use in the prevention of insulin resistance.
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