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Articles by Rosa Martha Perez Gutierrez
Total Records ( 2 ) for Rosa Martha Perez Gutierrez
  Rosa Martha Perez Gutierrez , Vicente Aguiniga Juarez , Jahel Valdes Sauceda and Irasema Anaya Sosa
  In this study the antidiabetic and antiglycation effects of Apium graveolens was evaluated. Streptozotozin-induced diabetic rats type 1 and 2 were orally treated with chloroform extract (AG-C) for 30 days. The extract (400 mg kg-1) showed good oral glucose tolerance test, effect in both normoglycaemic and hyperglycaemic rats, an antioxidant effect decreasing in the serum level of TBARS and gave its optimum antioxidant enzymes, in liver, kidney and pancreas, decrease levels of glucose and glycosylated hemoglobin, reduced total cholesterol, low-density cholesterol and triglycerides, while increased high-density cholesterol, aspartate, alanine aminotransferase, alkaline phosphatase, total bilirubin, total protein and insulin in serum and pancreas. Also protected RIN-5F cells from AGEs-induced oxidative stress. Gluconeogenic enzymes was significantly increased while hexokinase was decreased in the liver along with glycogen. The AG-C have a significant anti-glycative activity in vitro and it can also effectively protect the BSA during glycation. Their capacity to scavenge methylglyoxal suggested carbonyl scavenging as a major mechanism of antiglycation and showed potent Amadorin activity when compared to aminoguanidine. The AG-C after 30 days of treatment had beneficial effects on renal metabolic abnormalities, including oxidative stress and AGE formation. Results, support that AG-C improves glucose metabolism by reducing insulin resistance and stimulating insulin production by protecting pancreatic β-cells from oxidative stress, inhibits lipid abnormalities and have a hepatoprotective and renalprotective role. The close relationship between lipid peroxidation and nonenzymatic protein glycation (AGEs/ALEs) suggests that the antidiabetic activity of the celery could be due to the synergistic effect of antioxidant activity and antiglycation activity.
  Rosa Martha Perez Gutierrez
  Objective: Prosthechea michuacana is a Orchidaceae used as anti-inflammatory, to depurate the circulatory system, treat renal disease and diabetes. The aim of present study was to investigate the effect of two new triterpenes isolated from hexane extract from bulbs of Prosthechea michuacana in streptozotocin plus nicotinamide-induced type 2 diabetic mice. Method: Tetracyclic triterpenoids have been isolated from the bulbs hexane extract from P. michuacana which were identified by spectroscopic analysis to be 24-methyl, 24-hydroxy-5α-lanosta-9 (11), 25-dien-3α-acetate (1) and 24-methyl-24-hydroxy-5-lanosta 9(11)-en-3α acetate (2). Streptozotocin-nicotinamide-induced mildly diabetic mice was established to investigate the antidiabetic activities. The present study evaluated the effect of hypoglycaemic, hypolipidemic, oxidative stress, insulin resistance, of the triterpenoid 1 and 2 from P. michuacana. Diabetic mice were treated with 1 and 2 for a 30 days period and a set of biochemical parameters were studied including: Glucose level, total cholesterol, triglycerides, lipid peroxidation, liver and muscle glycogen, superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase, effect on RIN-5F cells from AGEs-induced oxidative stress and TNF-α and IL-6 levels in serum. We also looked into liver function by determining glucose-6-phosphatase, glucokinase and hexokinase activities and the effect on insulin level. Results: Both triterpenes significantly reduced the intake of food, water and body weight loss as well as levels of blood glucose, serum cholesterol, triglyceride, lipoprotein and increase HDL-cholesterol. The treatment improves TBARS-reactive substance level and SOD, CAT, GSH and GPX. The administration of 20 mg kg-1 exhibited a significant increase in serum and pancreas tissue insulin. The triterpenes decreased serum glucose in streptozotocin-nicotinamide-induced mildly diabetic mice protect the pancreas-derived β-cells from oxidative stress and increased insulin release from the beta cells of the pancreas in cultured RIN-5F cells. Also, decreased the level of serum of IL-6 and TNF-α in the diabetic mice. This suggests that the triterpenoids affect the serum insulin level and also may reduce insulin resistance by decreasing serum TNF-α. Conclusion: From these results, 1 and 2 are suggested to show anti-diabetic effect by stimulating insulin-dependent and by protecting pancreatic β-cells from oxidative stress and also may be an anti-obese, anti-insulin resistance and antihyperglycemic pro-drug.
 
 
 
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